Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue.
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Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factorGentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitorsSH2B1β interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiationIdentification of a murine TEF-1-related gene expressed after mitogenic stimulation of quiescent fibroblasts and during myogenic differentiationOrganization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding proteinBinding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity.Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 betaIdentification of a cysteine-rich receptor for fibroblast growth factorsAn acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonistThe HIV-1 TAT protein induces the expression and extracellular appearance of acidic fibroblast growth factorThe protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2Refinement of the structure of human basic fibroblast growth factor at 1.6 A resolution and analysis of presumed heparin binding sites by selenate substitution.Cloning of two novel forms of human acidic fibroblast growth factor (aFGF) mRNA.Transport of exogenous growth factors and cytokines to the cytosol and to the nucleus.Fibroblast growth factor receptor-1 interacts with the T-cell receptor signalling pathway.Activation of the MAP kinase pathway by FGF-1 correlates with cell proliferation induction while activation of the Src pathway correlates with migration.The FGF receptor-1 tyrosine kinase domain regulates myogenesis but is not sufficient to stimulate proliferation.Isolation of peptides that inhibit binding of basic fibroblast growth factor to its receptor from a random phage-epitope libraryStructure-function studies of acidic fibroblast growth factor.Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy.Structural and functional characterization of full-length heparin-binding growth associated molecule.A six-amino acid deletion in basic fibroblast growth factor dissociates its mitogenic activity from its plasminogen activator-inducing capacity.An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities.A requirement for fibroblast growth factor in regulation of skeletal muscle growth and differentiation cannot be replaced by activation of platelet-derived growth factor signaling pathways.Basic fibroblast growth factor requires a long-lasting activation of protein kinase C to induce cell proliferation in transformed fetal bovine aortic endothelial cells.FGF1 C-terminal domain and phosphorylation regulate intracrine FGF1 signaling for its neurotrophic and anti-apoptotic activitiesMonomer complexes of basic fibroblast growth factor and heparan sulfate oligosaccharides are the minimal functional unit for cell activation.FGF2-Heparin co-crystal complex-assisted design of mutants FGF1 and FGF7 with predictable heparin affinities.Transcriptional activation of fibroblast growth factor 1.B promoter is mediated through an 18-base pair cis-acting element.Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.FGF-1-dependent proliferative and migratory responses are impaired in senescent human umbilical vein endothelial cells and correlate with the inability to signal tyrosine phosphorylation of fibroblast growth factor receptor-1 substrates.The mitogenic activity of fibroblast growth factor-1 correlates with its internalization and limited proteolytic processing.Requirement of phosphatidylinositol 3-kinase activity for translocation of exogenous aFGF to the cytosol and nucleus.Fibroblast growth factor-1-inducible gene FR-17 encodes a nonmuscle alpha-actinin isoform.Effects of mutations of a phosphorylation site in an exposed loop in acidic fibroblast growth factor.Single-step purification on DEAE-sephacel of recombinant polypeptides produced in Escherichia coli.Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase.Inability of the acidic fibroblast growth factor mutant K132E to stimulate DNA synthesis after translocation into cells.Identification and characterization of a fibroblast growth factor (FGF) binding domain in the cysteine-rich FGF receptor.Effect of extension of the heparin binding pocket on the structure, stability, and cell proliferation activity of the human acidic fibroblast growth factor.
P2860
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P2860
Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Possible dissociation of the h ...... is of a single lysine residue.
@ast
Possible dissociation of the h ...... is of a single lysine residue.
@en
type
label
Possible dissociation of the h ...... is of a single lysine residue.
@ast
Possible dissociation of the h ...... is of a single lysine residue.
@en
prefLabel
Possible dissociation of the h ...... is of a single lysine residue.
@ast
Possible dissociation of the h ...... is of a single lysine residue.
@en
P2093
P2860
P356
P1476
Possible dissociation of the h ...... is of a single lysine residue.
@en
P2093
P2860
P304
P356
10.1083/JCB.111.5.2129
P407
P433
P577
1990-11-01T00:00:00Z