High affinity germinal center B cells are actively selected into the plasma cell compartment.
about
A role for DRAK2 in the germinal center reaction and the antibody responseRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationAlloantibody Generation and Effector Function Following Sensitization to Human Leukocyte AntigenRegulation of germinal center B-cell differentiationMolecular programming of B cell memoryActivation of B cells by non-canonical helper signalsDeconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and ImmunityHumanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Affinity of antigen encounter and other early B-cell signals determine B-cell fate.Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signalingGerminal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter.Quantal and graded stimulation of B lymphocytes as alternative strategies for regulating adaptive immune responsesLong-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivaxAdjuvant-specific regulation of long-term antibody responses by ZBTB20IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism.Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.Antigen affinity discrimination is an intrinsic function of the B cell receptor.It's all about change: the antigen-driven initiation of B-cell receptor signalingImmunogenomic engineering of a plug-and-(dis)play hybridoma platform.Intraclonal competition inhibits the formation of high-affinity antibody-secreting cellsHIV-1 infection in Zambian children impairs the development and avidity maturation of measles virus-specific immunoglobulin G after vaccination and infection.Germinal center selection and the development of memory B and plasma cells.Long-lived bone marrow plasma cells are induced early in response to T cell-independent or T cell-dependent antigens.Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice.The generation of antibody-secreting plasma cells.Soma-to-germline feedback is implied by the extreme polymorphism at IGHV relative to MHC: The manifest polymorphism of the MHC appears greatly exceeded at Immunoglobulin loci, suggesting antigen-selected somatic V mutants penetrate Weismann's BarrieLocal renal autoantibody production in lupus nephritisThe immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module.An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling.Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactionsDifferential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells.Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants.An extrafollicular pathway for the generation of effector CD8(+) T cells driven by the proinflammatory cytokine, IL-12.The tipping points in the initiation of B cell signalling: how small changes make big differences.Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.Focused transcription from the human CR2/CD21 core promoter is regulated by synergistic activity of TATA and Initiator elements in mature B cells.The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development.Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte MemoryAffinity maturation of antibodies requires integrity of the adult thymus
P2860
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P2860
High affinity germinal center B cells are actively selected into the plasma cell compartment.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
High affinity germinal center ...... o the plasma cell compartment.
@ast
High affinity germinal center ...... o the plasma cell compartment.
@en
type
label
High affinity germinal center ...... o the plasma cell compartment.
@ast
High affinity germinal center ...... o the plasma cell compartment.
@en
prefLabel
High affinity germinal center ...... o the plasma cell compartment.
@ast
High affinity germinal center ...... o the plasma cell compartment.
@en
P2093
P2860
P356
P1476
High affinity germinal center ...... to the plasma cell compartment
@en
P2093
Antony Basten
Didrik Paus
Marian L Turner
Robert Brink
Tyani D Chan
P2860
P304
P356
10.1084/JEM.20061254
P407
P577
2006-10-09T00:00:00Z