Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse. - Wikidata - awgldk - TriplyDB

Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse.

Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse.

http://www.wikidata.org/entity/Q36228985

about

Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation Cell biological steps and checkpoints in accessing NK cell cytotoxicity Distinct Roles of Cytoskeletal Components in Immunological Synapse Formation and Directed Secretion.Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion.Regulation of the formation and trafficking of vesicles from Golgi by PCH family proteins during chemotaxis Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse.Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment.Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42 Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling Systemic lupus erythematosus and Wiskott-Aldrich syndrome in an Italian patient.Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity Wiskott-Aldrich syndrome: a comprehensive review.Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity.Navigating barriers: the challenge of directed secretion at the natural killer cell lytic immunological synapse.Chipping away at gamma-H2AX foci.Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation.Cdc42-mediated MTOC polarization in dendritic cells controls targeted delivery of cytokines at the immune synapse.Functional characterization of Trip10 in cancer cell growth and survival.Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3.IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.PTEN is a negative regulator of NK cell cytolytic function.HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing.Cdc42-Interacting Protein 4 Represses E-Cadherin Expression by Promoting β-Catenin Translocation to the Nucleus in Murine Renal Tubular Epithelial Cells.Centrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells Human NK cell lytic granules and regulation of their exocytosis Gene therapy for Wiskott-Aldrich Syndrome-Long-term reconstitution and clinical benefits, but increased risk for leukemogenesis.Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.Line of attack: NK cell specificity and integration of signals.The killer's kiss: the many functions of NK cell immunological synapses.Essential role of the Ly49A stalk region for immunological synapse formation and signaling.Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity.Lytic granule polarization, rather than degranulation, is the preferred target of inhibitory receptors in NK cells.Signal transduction during activation and inhibition of natural killer cells.Formation and function of the lytic NK-cell immunological synapse.Controlling natural killer cell responses: integration of signals for activation and inhibition.Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity.AKAP350 Is involved in the development of apical "canalicular" structures in hepatic cells HepG2.

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P2860

Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse.

http://www.wikidata.org/entity/Q36228985

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Cdc42-interacting protein-4 fu ...... NK cell immunological synapse.

@ast

Cdc42-interacting protein-4 fu ...... NK cell immunological synapse.

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type

label

Cdc42-interacting protein-4 fu ...... NK cell immunological synapse.

@ast

Cdc42-interacting protein-4 fu ...... NK cell immunological synapse.

@en

prefLabel

Cdc42-interacting protein-4 fu ...... NK cell immunological synapse.

@ast

Cdc42-interacting protein-4 fu ...... NK cell immunological synapse.

@en

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P1433

Journal of Experimental Medicine

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Cdc42-interacting protein-4 fu ...... NK cell immunological synapse

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P2093

Linda Monaco-Shawver

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Megan M Suhoski

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Pinaki P Banerjee

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Rahul Pandey

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Rena Zheng

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P2860

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling

A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton

Human decidual NK cells form immature activating synapses and are not cytotoxic.

Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis

Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules

The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages

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2305-2320

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10

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204

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6054040

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17785506

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2118451

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