Structural features and domain organization of huntingtin fibrils.
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Molecular mechanisms of disease-causing missense mutationsAn Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril FormationConformational switching in PolyGln amyloid fibrils resulting from a single amino acid insertion.Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine coreMonomeric, oligomeric and polymeric proteins in huntington disease and other diseases of polyglutamine expansionInvestigating the structural impact of the glutamine repeat in huntingtin assembly.Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation.Polyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state nuclear magnetic resonance.Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopyThe emerging role of the first 17 amino acids of huntingtin in Huntington's diseaseHuntingtin N-Terminal Monomeric and Multimeric Structures Destabilized by Covalent Modification of Heteroatomic Residues.Solid-State Nuclear Magnetic Resonance on the Static and Dynamic Domains of Huntingtin Exon-1 Fibrils.The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtinAcetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding.Nanoscale studies link amyloid maturity with polyglutamine diseases onset.Identification and Structural Characterization of the N-terminal Amyloid Core of Orb2 isoform A.Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils.Polyphenols Beyond Barriers: A Glimpse into the Brain.Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models.Aggregation behavior of chemically synthesized, full-length huntingtin exon1.Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties.β-hairpin-mediated nucleation of polyglutamine amyloid formation.Could yeast prion domains originate from polyQ/N tracts?Architecture of polyglutamine-containing fibrils from time-resolved fluorescence decay.Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.Lysine residues in the N-terminal huntingtin amphipathic α-helix play a key role in peptide aggregation.Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths.The 17-residue-long N terminus in huntingtin controls step-wise aggregation in solution and on membranes via different mechanisms.Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers.
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P2860
Structural features and domain organization of huntingtin fibrils.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Structural features and domain organization of huntingtin fibrils.
@ast
Structural features and domain organization of huntingtin fibrils.
@en
type
label
Structural features and domain organization of huntingtin fibrils.
@ast
Structural features and domain organization of huntingtin fibrils.
@en
prefLabel
Structural features and domain organization of huntingtin fibrils.
@ast
Structural features and domain organization of huntingtin fibrils.
@en
P2093
P2860
P356
P1476
Structural features and domain organization of huntingtin fibrils.
@en
P2093
Charles W Bugg
J Mario Isas
Paul H Patterson
Ralf Langen
Torsten Fischer
P2860
P304
31739-31746
P356
10.1074/JBC.M112.353839
P407
P577
2012-07-16T00:00:00Z