The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain - Wikidata - awgldk - TriplyDB

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

http://www.wikidata.org/entity/Q36236290

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β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1 Emerging role of Hippo pathway in gastric and other gastrointestinal cancers The TEAD Family and Its Oncogenic Role in Promoting Tumorigenesis The H19 Long non-coding RNA in cancer initiation, progression and metastasis - a proposed unifying theory Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.Emerging role of cell polarity proteins in breast cancer progression and metastasis The emerging molecular machinery and therapeutic targets of metastasis The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.Repair Injured Heart by Regulating Cardiac Regenerative Signals Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy Targeting the VEGF-C/VEGFR3 axis suppresses Slug-mediated cancer metastasis and stemness via inhibition of KRAS/YAP1 signaling Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3 Impact of the physical microenvironment on tumor progression and metastasis Deregulation of the Hippo pathway in mouse mammary stem cells promotes mammary tumorigenesis.Fluid shear stress activates YAP1 to promote cancer cell motility The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells.YAP-Hippo signalling downstream of leukemia inhibitory factor receptor: implications for breast cancer.Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion.The Hippo pathway in disease and therapy: cancer and beyond KRAS and YAP1 converge to regulate EMT and tumor survival A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12.Metabolic profiling reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity.α-catenin. A tumor suppressor beyond adherens junctions.MiR-506 suppresses proliferation of hepatoma cells through targeting YAP mRNA 3'UTR.Microenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell's Journey.Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response.YAP promotes ovarian cancer cell tumorigenesis and is indicative of a poor prognosis for ovarian cancer patients.FGF8 promotes colorectal cancer growth and metastasis by activating YAP1.The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells.Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors.Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling.Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis.A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma.YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

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The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

http://www.wikidata.org/entity/Q36236290

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2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

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The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

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The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

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The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

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The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

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The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

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Proceedings of the National Academy of Sciences of the United States of America

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The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

@en

P2093

Hui Liu

http://www.w3.org/2001/XMLSchema#string

Jeffrey W Schindler

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John M Lamar

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Patrick Stern

http://www.w3.org/2001/XMLSchema#string

Richard O Hynes

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Zhi-Gang Jiang

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P2860

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)

Yap1 acts downstream of α-catenin to control epidermal proliferation

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Tumor suppressor LATS1 is a negative regulator of oncogene YAP

Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

TEAD mediates YAP-dependent gene induction and growth control

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

The hippo signaling pathway in development and cancer

α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1

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