KRAS and YAP1 converge to regulate EMT and tumor survival - Wikidata - awgldk - TriplyDB

KRAS and YAP1 converge to regulate EMT and tumor survival

KRAS and YAP1 converge to regulate EMT and tumor survival

http://www.wikidata.org/entity/Q33946244

about

Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover Multifunctional DDX3: dual roles in various cancer development and its related signaling pathways Genetics and biology of pancreatic ductal adenocarcinoma Emerging role of Hippo pathway in gastric and other gastrointestinal cancers Role of cancer-associated fibroblasts in invasion and metastasis of gastric cancer KRAS as a Therapeutic Target Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.CRISPR-Cas9: from Genome Editing to Cancer Research Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy Targeting the VEGF-C/VEGFR3 axis suppresses Slug-mediated cancer metastasis and stemness via inhibition of KRAS/YAP1 signaling Oncogenic Signaling Adaptor Proteins EMT, CTCs and CSCs in tumor relapse and drug-resistance Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.Regulation of localization and function of the transcriptional co-activator YAP by angiomotin.Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers.YAP regulates cell mechanics by controlling focal adhesion assembly.Phase I/Ib study of olaparib and carboplatin in women with triple negative breast cancer.KRAS-dependent suppression of MYC enhances the sensitivity of cancer cells to cytotoxic agents.The YAP1/SIX2 axis is required for DDX3-mediated tumor aggressiveness and cetuximab resistance in KRAS-wild-type colorectal cancer.The cell polarity protein Scrib functions as a tumor suppressor in liver cancer.Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration.Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover Forward genetic screens in mice uncover mediators and suppressors of metastatic reactivation.Drugging the undruggable RAS: Mission possible?Clonality and evolutionary history of rhabdomyosarcoma FGF8 promotes colorectal cancer growth and metastasis by activating YAP1.Mutant KRAS as a critical determinant of the therapeutic response of colorectal cancer.Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling.Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma.Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation.Genetics, diagnosis and management of colorectal cancer (Review).

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KRAS and YAP1 converge to regulate EMT and tumor survival

http://www.wikidata.org/entity/Q33946244

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2014 nî lūn-bûn

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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

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2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

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name

KRAS and YAP1 converge to regulate EMT and tumor survival

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KRAS and YAP1 converge to regulate EMT and tumor survival

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type

label

KRAS and YAP1 converge to regulate EMT and tumor survival

@ast

KRAS and YAP1 converge to regulate EMT and tumor survival

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prefLabel

KRAS and YAP1 converge to regulate EMT and tumor survival

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KRAS and YAP1 converge to regulate EMT and tumor survival

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J.CELL.2014.06.004

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P1476

KRAS and YAP1 converge to regulate EMT and tumor survival

@en

P2093

Anna C Schinzel

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Arjun Bhutkar

http://www.w3.org/2001/XMLSchema#string

David E Root

http://www.w3.org/2001/XMLSchema#string

Diane D Shao

http://www.w3.org/2001/XMLSchema#string

Elsa B Krall

http://www.w3.org/2001/XMLSchema#string

Federica Piccioni

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Jong W Kim

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Sabina Sood

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Thomas M Roberts

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Tyler Jacks

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P2860

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

TEAD mediates YAP-dependent gene induction and growth control

Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

The hippo signaling pathway in development and cancer

TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

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171-184

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scholarly article

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10.1016/J.CELL.2014.06.004

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1

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158

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Joseph Rosenbluh

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2014-06-19T00:00:00Z

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24954536

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4110062

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