alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor
about
Recycling of the urokinase receptor upon internalization of the uPA:serpin complexesDirect binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activityMannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interactionPlasminogen Activator System and Breast Cancer: Potential Role in Therapy Decision Making and Precision MedicineCollagenase-3 binds to a specific receptor and requires the low density lipoprotein receptor-related protein for internalizationAnalysis of a two-domain binding site for the urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex in low-density-lipoprotein-receptor-related proteinThe very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitro.Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner.Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth.The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces.Regulation of Rac1 activation by the low density lipoprotein receptor-related proteinEpidermal growth factor and platelet-derived growth factor-BB induce a stable increase in the activity of low density lipoprotein receptor-related protein in vascular smooth muscle cells by altering receptor distribution and recycling.Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor system and accelerated migration on vitronectin.Number and brightness image analysis reveals ATF-induced dimerization kinetics of uPAR in the cell membraneClathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.LRP1 regulates remodeling of the extracellular matrix by fibroblasts.Up-regulated expression of type II very low density lipoprotein receptor correlates with cancer metastasis and has a potential link to β-catenin in different cancersThe putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration.Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule.LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome.The kidney in vitamin B12 and folate homeostasis: characterization of receptors for tubular uptake of vitamins and carrier proteins.The molecular basis for anti-proteolytic and non-proteolytic functions of plasminogen activator inhibitor type-1: roles of the reactive centre loop, the shutter region, the flexible joint region and the small serpin fragment.Regulation of arterial remodeling and angiogenesis by urokinase-type plasminogen activator.Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3'-kinase-dependent machinery.Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptorUrokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase.Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death.Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrins.Maspin increases extracellular plasminogen activator activity associated with corneal fibroblasts and myofibroblasts.uPA and PAI-1 as biomarkers in breast cancer: validated for clinical use in level-of-evidence-1 studies.Lipids as targeting signals: lipid rafts and intracellular trafficking.Lipoprotein receptor-related protein 1 regulates collagen 1 expression, proteolysis, and migration in human pleural mesothelial cells.LRP-1 silencing prevents malignant cell invasion despite increased pericellular proteolytic activitiesLactoferrin promotes collagen gel contractile activity of fibroblasts mediated by lipoprotein receptors.Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptorThe inhibitory effect of HKa in endothelial cell tube formation is mediated by disrupting the uPA-uPAR complex and inhibiting its signaling and internalization.Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidineRole of urokinase receptor in tumor progression and development.Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells.
P2860
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P2860
alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
alpha-2 Macroglobulin receptor ...... tion of the urokinase receptor
@ast
alpha-2 Macroglobulin receptor ...... tion of the urokinase receptor
@en
type
label
alpha-2 Macroglobulin receptor ...... tion of the urokinase receptor
@ast
alpha-2 Macroglobulin receptor ...... tion of the urokinase receptor
@en
prefLabel
alpha-2 Macroglobulin receptor ...... tion of the urokinase receptor
@ast
alpha-2 Macroglobulin receptor ...... tion of the urokinase receptor
@en
P2093
P2860
P356
P1476
alpha-2 Macroglobulin receptor ...... tion of the urokinase receptor
@en
P2093
Andreasen PA
Christensen EI
Gliemann J
Petersen CM
P2860
P304
P356
10.1083/JCB.131.6.1609
P407
P433
P577
1995-12-01T00:00:00Z