about
The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRsFluorescent approaches for understanding interactions of ligands with G protein coupled receptorsTools for GPCR drug discovery.Activation biosensor for G protein-coupled receptors: a FRET-based m1 muscarinic activation sensor that regulates G(q)Data quality in drug discovery: the role of analytical performance in ligand binding assays.Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.Pharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand-receptor complexes.Novel Alexa Fluor-488 labeled antagonist of the A(2A) adenosine receptor: Application to a fluorescence polarization-based receptor binding assay.Development of a fluorescence assay for the characterization of brevenal binding to rat brain synaptosomes.Biophysical characterization of G-protein coupled receptor-peptide ligand binding.GPCR ligand dendrimer (GLiDe) conjugates: adenosine receptor interactions of a series of multivalent xanthine antagonistsBodilisant-a novel fluorescent, highly affine histamine h3 receptor ligandChemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs.Novel fluorescent antagonist as a molecular probe in A(3) adenosine receptor binding assays using flow cytometry.Lighting up G protein-coupled purinergic receptors with engineered fluorescent ligands.Fluorescent ligands for adenosine receptors.Fluorescent agonists and antagonists for vasopressin/oxytocin G protein-coupled receptors: usefulness in ligand screening assays and receptor studies.Dual labeled peptides as tools to study receptors: nanomolar affinity derivatives of TIPP (Tyr-Tic-Phe-Phe) containing an affinity label and biotin as probes of delta opioid receptors.Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC.Chemical labelling for visualizing native AMPA receptors in live neurons.Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies.Escaping the flatlands: new approaches for studying the dynamic assembly and activation of GPCR signaling complexes.Monitoring Gq-coupled receptor response through inositol phosphate quantification with the IP-One assay.Advances and challenges in high-throughput microscopy for live-cell subcellular imaging.An update of novel screening methods for GPCR in drug discovery.Structure-function studies with G protein-coupled receptors as a paradigm for improving drug discovery and development of therapeutics.The A, B, Cs of G-protein-coupled receptor pharmacology in assay development for HTS.Beyond radio-displacement techniques for identification of CB1 ligands: the first application of a fluorescence-quenching assay.Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cellsInfluence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands.Exploiting Fluorescence Lifetime Plasticity in FLIM: Target Molecule Localization in Cells and Tissues.Development of a competitive fluorescence-based synaptosome binding assay for brevetoxinsA simple and powerful flow cytometric method for the simultaneous determination of multiple parameters at G protein-coupled receptor subtypes.A novel fluorescent histamine H(1) receptor antagonist demonstrates the advantage of using fluorescence correlation spectroscopy to study the binding of lipophilic ligands.Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors.Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP.Synthesis of BODIPY derivatives substituted with various bioconjugatable linker groups: a construction kit for fluorescent labeling of receptor ligands.Development of a homogeneous high-throughput live-cell G-protein-coupled receptor binding assay.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Fluorophore-tagged GPCR ligands.
@ast
Fluorophore-tagged GPCR ligands.
@en
type
label
Fluorophore-tagged GPCR ligands.
@ast
Fluorophore-tagged GPCR ligands.
@en
prefLabel
Fluorophore-tagged GPCR ligands.
@ast
Fluorophore-tagged GPCR ligands.
@en
P1476
Fluorophore-tagged GPCR ligands
@en
P2093
Richard J Middleton
P304
P356
10.1016/J.CBPA.2005.08.016
P577
2005-10-01T00:00:00Z