Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus. - Wikidata - awgldk - TriplyDB

Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus.

Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus.

http://www.wikidata.org/entity/Q36242842

about

A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells Lentiviral gene transfer of RPE65 rescues survival and function of cones in a mouse model of Leber congenital amaurosis Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue.Latent adeno-associated virus infection elicits humoral but not cell-mediated immune responses in a nonhuman primate model Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness Comparative analysis of DNA nanoparticles and AAVs for ocular gene delivery Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey MicroRNA-restricted transgene expression in the retina Structural Insights into Adeno-Associated Virus Serotype 5 Gene transfer mediated by recombinant baculovirus into mouse eye Gene therapy prevents photoreceptor death and preserves retinal function in a Bardet-Biedl syndrome mouse model.Potential long-term inhibition of ocular neovascularisation by recombinant adeno-associated virus-mediated secretion gene therapy.Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization Recombinant adeno-associated virus vector expressing angiostatin inhibits preretinal neovascularization in adult rats.Genetic fate of recombinant adeno-associated virus vector genomes in muscle Long-term safety of GDNF gene delivery in the retina.Efficient non-viral ocular gene transfer with compacted DNA nanoparticles.XIAP protection of photoreceptors in animal models of retinitis pigmentosa.Designer gene delivery vectors: molecular engineering and evolution of adeno-associated viral vectors for enhanced gene transfer Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential In vivo imaging of microscopic structures in the rat retina Cloning and characterization of adeno-associated virus type 5.The Gordon Wilson Lecture. From basic virology to human gene therapy.Adeno-associated virus vectors and hematology Adeno-associated viral vectors for gene transfer and gene therapy.Structure of adeno-associated virus type 4.Self-complementary AAV5 vector facilitates quicker transgene expression in photoreceptor and retinal pigment epithelial cells of normal mouse.An evolved adeno-associated viral variant enhances gene delivery and gene targeting in neural stem cells Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: cell cycling does not influence hepatocyte transduction.Design and packaging of adeno-associated virus gene targeting vectors Structured illumination multimodal 3D-resolved quantitative phase and fluorescence sub-diffraction microscopy.AAV2-mediated subretinal gene transfer of hIFN-α attenuates experimental autoimmune uveoretinitis in mice.Recent advances in the molecular basis of inherited photoreceptor degeneration.Gene therapy and retinitis pigmentosa: advances and future challenges.Replacement gene therapy with a human RPGRIP1 sequence slows photoreceptor degeneration in a murine model of Leber congenital amaurosis.P2Y(2) receptor agonist INS37217 enhances functional recovery after detachment caused by subretinal injection in normal and rds mice.Immune response following intraocular delivery of recombinant viral vectors.

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P2860

Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus.

http://www.wikidata.org/entity/Q36242842

description

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Proceedings of the National Academy of Sciences of the United States of America

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Efficient photoreceptor-target ...... binant adeno-associated virus.

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J G Flannery

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M I Vaquero

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M M LaVail

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N Muzyczka

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S Zolotukhin

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W W Hauswirth

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P2860

Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa

Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors

Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis

Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy

Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos

Human photoreceptor topography.

DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors

Use of adeno-associated virus as a general transduction vector for mammalian cells.

Doyne Lecture. Rhodopsin and autosomal dominant retinitis pigmentosa.

Adeno-associated virus vectors preferentially transduce cells in S phase.

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Photoreceptor protein

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21259

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