ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets. - Wikidata - awgldk - TriplyDB

ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets.

ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets.

http://www.wikidata.org/entity/Q36252693

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Melanoma: from melanocyte to genetic alterations and clinical options Melanoma Cancer Stem Cells: Markers and Functions Aldehyde dehydrogenase 1A1 in stem cells and cancer Aldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumors Molecular biomarkers of cancer stem/progenitor cells associated with progression, metastases, and treatment resistance of aggressive cancers Stem cells and targeted approaches to melanoma cure Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders A synthetic modular approach for modeling the role of the 3D microenvironment in tumor progression Alternative Treatments For Melanoma: Targeting BCL-2 Family Members to De-Bulk and Kill Cancer Stem Cells Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid KDM4C, a H3K9me3 Histone Demethylase, is Involved in the Maintenance of Human ESCC-Initiating Cells by Epigenetically Enhancing SOX2 Expression Topical treatment of melanoma metastases with imiquimod, plus administration of a cancer vaccine, promotes immune signatures in the metastases.Proteomic Upregulation of Fatty Acid Synthase and Fatty Acid Binding Protein 5 and Identification of Cancer- and Race-Specific Pathway Associations in Human Prostate Cancer Tissues.Arsenic trioxide induces differentiation of CD133+ hepatocellular carcinoma cells and prolongs posthepatectomy survival by targeting GLI1 expression in a mouse model The soy-derived peptide Lunasin inhibits invasive potential of melanoma initiating cells ALDH1A1 expression correlates with clinicopathologic features and poor prognosis of breast cancer patients: a systematic review and meta-analysis Aldehyde dehydrogenases: from eye crystallins to metabolic disease and cancer stem cells SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells.Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma Phenotypic, genomic and functional characterization reveals no differences between CD138++ and CD138low subpopulations in multiple myeloma cell lines ALDH maintains the stemness of lung adenoma stem cells by suppressing the Notch/CDK2/CCNE pathway.NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells.Gene expression profiling identifies microphthalmia-associated transcription factor (MITF) and Dickkopf-1 (DKK1) as regulators of microenvironment-driven alterations in melanoma phenotype Cancer stem cells as a target population for drug discovery.Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.Coating Solid Lipid Nanoparticles with Hyaluronic Acid Enhances Antitumor Activity against Melanoma Stem-like Cells.Cancer stem cell vaccine inhibits metastases of primary tumors and induces humoral immune responses against cancer stem cells MiR-187 Targets the Androgen-Regulated Gene ALDH1A3 in Prostate Cancer.Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway.A STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations.ALDH1A3: A Marker of Mesenchymal Phenotype in Gliomas Associated with Cell Invasion ALDH3A1 Plays a Functional Role in Maintenance of Corneal Epithelial Homeostasis Survival of skin cancer stem cells requires the Ezh2 polycomb group protein.Iterative sorting reveals CD133+ and CD133- melanoma cells as phenotypically distinct populations.Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma.Understanding melanoma stem cells TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF.Cancer stem cells and tumor transdifferentiation: implications for novel therapeutic strategies.

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ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets.

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David A Norris

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David C Thompson

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Dennis R Roop

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Katiuscia Dallaglio

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Martin D McCarter

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Mayumi Fujita

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Rene Gonzalez

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Steven E Robinson

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William A Robinson

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Ying Chen

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P2860

VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271

Identification of cells initiating human melanomas

Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis

Efficient tumour formation by single human melanoma cells

Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells

Stem cells, cancer, and cancer stem cells

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2100-2113

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10.1002/STEM.1193

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10

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30

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Vasilis Vasiliou

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230658741

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