Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis. - Wikidata - awgldk - TriplyDB

Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis.

Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis.

http://www.wikidata.org/entity/Q36253834

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Targeting Src family kinases in anti-cancer therapies: turning promise into triumph Mechanistic evaluation of a novel small molecule targeting mitochondria in pancreatic cancer cells Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases Combination of dasatinib and gemcitabine reduces the ALDH1A1 expression and the proliferation of gemcitabine-resistant pancreatic cancer MIA PaCa-2 cells.Bosutinib reduces the efficacy of Dasatinib in triple-negative breast cancer cell lines.The tyrosine kinase inhibitor dasatinib induces a marked adipogenic differentiation of human multipotent mesenchymal stromal cells.Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion Elucidation of the roles of the Src kinases in pancreatic acinar cell signaling Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.Mechanisms underlying the cytotoxicity of a novel quinazolinedione-based redox modulator, QD232, in pancreatic cancer cells Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth Response to combined molecular targeting: defining the role of P-STAT3.Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells.Molecular targeted approaches for treatment of pancreatic cancer.Src kinases play a novel dual role in acute pancreatitis affecting severity but no role in stimulated enzyme secretion Emerging targets in pancreatic cancer: epithelial-mesenchymal transition and cancer stem cells SRC family kinases as novel therapeutic targets to treat breast cancer brain metastases.Integrative survival-based molecular profiling of human pancreatic cancer.Targeting the LKB1 tumor suppressor.Targeted inhibition of Src kinase with dasatinib blocks thyroid cancer growth and metastasis.Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells.Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway.Signal transducer and activator of transcription 3 inhibitors: a patent review.Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids.EZH2 coupled with HOTAIR to silence MicroRNA-34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma.Resolution of Novel Pancreatic Ductal Adenocarcinoma Subtypes by Global Phosphotyrosine Profiling.Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action.SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer.Naphtho[1,2-b]furan-4,5-dione inhibits MDA-MB-231 cell migration and invasion by suppressing Src-mediated signaling pathways.Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells.Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells.Dasatinib : a novel therapy for breast cancer?Impact of the SRC inhibitor dasatinib on the metastatic phenotype of human prostate cancer cells.LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells.Translational research in gastrointestinal oncology: a focus on signaling pathways in pancreas cancer.Src inhibition is still a relevant target in pancreatic cancer Phosphorylation of the C-Raf N-region promotes Raf dimerization.

P2860

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P2860

Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis.

http://www.wikidata.org/entity/Q36253834

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

@zh-cn

name

Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis.

@ast

Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis.

@en

type

label

Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis.

@ast

Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis.

@en

prefLabel

Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis.

@ast

Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis.

@en

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1535-7163.MCT-09-1212

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Molecular Cancer Therapeutics

P1476

Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis.

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P2093

Frank Revetta

http://www.w3.org/2001/XMLSchema#string

J Joshua Smith

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M Kay Washington

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Nagathihalli S Nagaraj

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Nipun B Merchant

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P2860

Src family kinases in tumor progression and metastasis

The role of Src in solid tumors

Induction of cyclin D1 by simian virus 40 small tumor antigen

Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer.

Paxillin and focal adhesion signalling

Signaling through focal adhesion kinase

Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase

Lack of mutation at codon 531 of SRC in advanced colorectal cancers from Italian patients

Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis

FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

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2322-2332

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10.1158/1535-7163.MCT-09-1212

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8

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9

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20682659

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3449211

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