Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis.
about
Enhancer complexes located downstream of both human immunoglobulin Calpha genesFormation of stable transcription complexes as assayed by analysis of individual templates.Enhancer activity correlates with the oncogenic potential of avian retrovirusesActivation of immunoglobulin mu gene expression involves stepwise demethylation.The long winding road toward understanding the molecular mechanisms for B-cell suppression by 2,3,7,8-tetrachlorodibenzo-p-dioxinHigh rates of deletions in the constant region segment of the immunoglobulin mu gene.Identification of 3' alpha-hs4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation.Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificityPosition-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.Evidence for transient requirement of the IgH enhancerXenopus ribosomal gene enhancers function when inserted inside the gene they enhance.Cell-type-specific and regulated expression of a human gamma 1 heavy-chain immunoglobulin gene in transgenic mice.An enhancer at the 3' end of the mouse immunoglobulin heavy chain locusStrong transcriptional activation of translocated c-myc genes occurs without a strong nearby enhancer or promoterImmunoglobulin mRNA stability varies during B lymphocyte differentiationComplementation between two cell lines lacking kappa enhancer activity: implications for the developmental control of immunoglobulin transcriptionNuclear activity from F9 embryonal carcinoma cells binding specifically to the enhancers of wild-type polyoma virus and PyEC mutant DNAs.Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening.The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region.NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiationImmunoglobulin heavy-chain enhancer is required to maintain transfected gamma 2A gene expression in a pre-B-cell lineThe coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated.Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line.The rat albumin promoter is composed of six distinct positive elements within 130 nucleotidesDNA rearrangement causes a high rate of spontaneous mutation at the immunoglobulin heavy-chain locus of a mouse myeloma cell line.Role of the Igh intronic enhancer Eμ in clonal selection at the pre-B to immature B cell transition.Transcription of a productively rearranged Ig VDJC alpha does not require the presence of HS4 in the IgH 3' regulatory regionHigh rate of somatic point mutation in vitro in and near the variable-region segment of an immunoglobulin heavy chain geneDeletion of a B-cell-specific enhancer affects transfected, but not endogenous, immunoglobulin heavy-chain gene expression.Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.Immunoglobulin heavy chain toxicity in plasma cells is neutralized by fusion to pre-B cellsImmunoglobulin gene transcription ceases upon deletion of a distant enhancer.Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.Activation of the c-myc oncogene by the immunoglobulin heavy-chain gene enhancer after multiple switch region-mediated chromosome rearrangements in a murine plasmacytomaCis-acting regulatory sequences promote high-frequency gene conversion between repeated sequences in mammalian cells.Role of the intronic elements in the endogenous immunoglobulin heavy chain locus. Either the matrix attachment regions or the core enhancer is sufficient to maintain expression.Expression of the (recombinant) endogenous immunoglobulin heavy-chain locus requires the intronic matrix attachment regions.Transcriptional and processing-level control of immunoglobulin gene expression.An element in the endogenous IgH locus stimulates gene targeting in hybridoma cells
P2860
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P2860
Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis.
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年学术文章
@wuu
1984年学术文章
@zh-cn
1984年学术文章
@zh-hans
1984年学术文章
@zh-my
1984年学术文章
@zh-sg
1984年學術文章
@yue
1984年學術文章
@zh
1984年學術文章
@zh-hant
name
Expression of immunoglobulin h ...... bulin enhancer element in cis.
@ast
Expression of immunoglobulin h ...... bulin enhancer element in cis.
@en
type
label
Expression of immunoglobulin h ...... bulin enhancer element in cis.
@ast
Expression of immunoglobulin h ...... bulin enhancer element in cis.
@en
prefLabel
Expression of immunoglobulin h ...... bulin enhancer element in cis.
@ast
Expression of immunoglobulin h ...... bulin enhancer element in cis.
@en
P2860
P356
P1476
Expression of immunoglobulin h ...... bulin enhancer element in cis.
@en
P2093
P2860
P304
P356
10.1073/PNAS.81.8.2452
P407
P577
1984-04-01T00:00:00Z