Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus. - Wikidata - awgldk - TriplyDB

Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.

Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.

http://www.wikidata.org/entity/Q35064395

about

Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development The embryonic function of germ cell nuclear factor is dependent on the DNA binding domain Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region.Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.Ectopic T cell receptor-α locus control region activity in B cells is suppressed by direct linkage to two flanking genes at once.Migration of antibody secreting cells towards CXCL12 depends on the isotype that forms the BCR.Transgenes of the mouse immunoglobulin heavy chain locus, lacking distal elements in the 3' regulatory region, are impaired for class switch recombination Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Accessibility control and machinery of immunoglobulin class switch recombination.Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements.Functional deficiency in IL-7 caused by an N-ethyl-N-nitrosourea-induced point mutation.Three-dimensional architecture of the IgH locus facilitates class switch recombination.Replacement of Igamma3 germ-line promoter by Igamma1 inhibits class-switch recombination to IgG3.Quantitative regulation of class switch recombination by switch region transcription.H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation ATM is required for efficient recombination between immunoglobulin switch regions.Development and selection of gammadelta T cells.An ENU-induced mutation in the lymphotoxin alpha gene impairs organogenesis of lymphoid tissues in C57BL/6 mice Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development.Neurotrophin-3 is expressed in a discrete subset of olfactory receptor neurons in the mouse.Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation.Deletional analyses reveal an essential role for the hs3b/hs4 IgH 3' enhancer pair in an Ig-secreting but not an earlier-stage B cell line.The role of germline promoters and I exons in cytokine-induced gene-specific class switch recombination.Comment on "Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappa B-dependent cytokine expression in fibroblasts".E-proteins directly regulate expression of activation-induced deaminase in mature B cells.Dwarfism in homozygous Agc1CreERT mice is associated with decreased expression of aggrecan.Enhanced expression of human cDNA by phosphoglycerate kinase promoter-puromycin cassette in the mouse transthyretin locus.Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice.Duplication of a germline promoter downstream of the IgH 3' regulatory region impairs class switch recombination.

P2860

Q27000758-B81EAD53-3526-4248-B7AF-2B119A42AD4F Q28271930-C402A93A-25BB-4A39-9EA7-474A06D78445 Q28511462-2B62E3B6-30C1-47C2-A9D1-5280C1A68A2B Q28593355-13E66205-A137-4894-9887-7A39FAD00B68 Q31150699-60B3FD61-F2C1-49DB-9E35-0A4F4E73F414 Q33591104-63A9A497-B211-4D9E-9749-D4B4C6E505EE Q33734070-EF660E66-42F2-4E6B-B6F1-801EB1421119 Q33761216-3BC5A20D-95FF-4ACE-81D0-238E8B51C6EE Q34259851-BBB30559-8CE4-4FF0-BED9-156C0A13055C Q34586354-EA1DB7FA-8194-4E71-9579-BA041F0B8959 Q34997657-69C4837E-69D0-4B88-B4EA-371BDC3033F9 Q35046836-F2E140A8-3BBA-492C-BC6E-9E68C46F1648 Q35068183-15D823C4-5D5A-4534-B9AD-91F65DE24287 Q35082618-A4F45B6F-1885-46A5-9161-7782B527DB07 Q35402437-36E29264-5ED3-49FE-96C7-5E62DDAEB8E1 Q35641616-1194907E-DAE0-42D2-A5A8-2C2CFDC3A750 Q36235676-E6C5A760-D050-4600-84F5-E940796F10AD Q36300042-35769BD8-3839-4CAB-B791-CD0E2BE84FE4 Q36369428-20212200-1857-4FBE-A75D-01F030512F17 Q36370913-A8BD9D17-599F-4C14-A2E1-1BFBBAD20EAC Q36399334-71E41092-42BC-4AB8-9A95-818AAF49F658 Q36732642-D75522D4-5FF2-417A-8B0B-94FDF72A95E9 Q36983562-5D2309D1-49BB-4B37-AF3B-BA1139B88BF8 Q37203980-51DCDEEB-CB3D-4D3D-91FB-D2A8A2756FBA Q37342819-2AA0EB63-E8A1-44D6-99ED-6C8BC7542969 Q38353434-6F2FBDF3-36F3-43C0-82F2-FAC42ACAC61C Q38785846-F72B8928-3693-4E8A-84C2-042B16C3B694 Q40790198-2C64B32C-BE50-40BE-B723-38BDE710984B Q42699528-C634CC66-75FE-4C50-90CF-9400E73AEDC7 Q42974567-B3225372-FB4B-4D79-BDF7-01C005863BC2 Q44419402-BEC5E887-B5AE-40EA-A44C-1EAD5B458878 Q47786037-6F7F33A3-CB31-4DA9-AC08-57814CFE70E6 Q51911284-607A66DB-5A6C-443B-95EA-44675CF9C6C3 Q52543976-5716046A-A0DF-4A4E-B473-F2135FD4731E Q55399141-B596E0A8-0005-41D3-B888-F3193971CAE2

P2860

Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.

http://www.wikidata.org/entity/Q35064395

description

1999 nî lūn-bûn

@nan

1999 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի մարտին հրատարակված գիտական հոդված

@hy

1999年の論文

@ja

1999年論文

@yue

1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

@zh-tw

1999年论文

@wuu

name

Position-dependent inhibition ...... y chain constant region locus.

@ast

Position-dependent inhibition ...... y chain constant region locus.

@en

type

label

Position-dependent inhibition ...... y chain constant region locus.

@ast

Position-dependent inhibition ...... y chain constant region locus.

@en

prefLabel

Position-dependent inhibition ...... y chain constant region locus.

@ast

Position-dependent inhibition ...... y chain constant region locus.

@en

P1433

Q35064395-680D7483-3A2A-4AAD-9757-FFF40EA21C9D

P1476

Q35064395-BBF38F65-3D72-4749-8EE1-64F76DED673C

P2093

Q35064395-2CCC5744-758F-4F50-AF54-F42214B62497

Q35064395-6496AD0D-9351-49BC-BB89-2D224E2F65F9

Q35064395-650F9424-7C7F-4BF9-96D5-545049174832

Q35064395-6EFEBEDC-8C1B-4409-8C1E-FE025BC87368

Q35064395-8319B349-FDE3-498F-A1B2-63DD731503E8

Q35064395-956D8CAF-B9FF-4448-844C-F997DF49C619

Q35064395-FBC1A7E8-B88E-4BC5-8959-E5BE309DE25A

Q35064395-FD4E5743-BD5C-4A4B-82B8-B5855F87775C

P2860

Q35064395-023D7B82-9B34-47DF-A9E0-5B254F14ED40

Q35064395-068399CA-CFDD-4F69-A208-AC71ECCCED11

Q35064395-08BD3A8F-3EA8-40B4-954C-7B3082296413

Q35064395-1909AC5B-41FC-4B83-8C04-7B91EEDC43A5

Q35064395-19437B41-6CCC-448E-852E-94A9C651D310

Q35064395-1A0B5665-B379-4AB7-9880-A36EAC80B4A5

Q35064395-2B6751AF-D168-4359-B18B-83DD18532AE0

Q35064395-3311E992-DE86-45CC-BB11-9E10E8E48280

Q35064395-39B7D2F4-E7E3-47BD-9BEB-07E034BB3A7D

Q35064395-39BEA93B-7F54-4FB6-8532-6DCEEA861A23

P304

Q35064395-7FBA2D41-3428-4CE0-8D90-46E1317BF476

P31

Q35064395-C6F31EDB-0EE7-4D75-BBB2-EC1EA2375701

P356

Q35064395-0FD245FA-EFCD-4819-9412-6511B4C1CE25

P407

Q35064395-6F6FBFCE-A278-4A0C-A9AA-9AAA8D632E06

P433

Q35064395-0B8A8FF7-F439-4519-919A-D1EADA3D2BEC

P478

Q35064395-5750A228-7DB6-4891-ADC5-2080BD6C9C58

P577

Q35064395-106DE39F-0726-469C-8773-027D3D525966

P5875

Q35064395-A568D640-0254-48F0-A2DF-B2817E391667

P698

Q35064395-47343480-C3E4-4687-BE81-917E0F72DE92

P932

Q35064395-B792ED84-7209-4E10-87A7-D79ECD995335

P356

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Position-dependent inhibition ...... y chain constant region locus.

@en

P2093

A Bottaro

http://www.w3.org/2001/XMLSchema#string

A Kisselgof

http://www.w3.org/2001/XMLSchema#string

F W Alt

http://www.w3.org/2001/XMLSchema#string

H Oettgen

http://www.w3.org/2001/XMLSchema#string

J P Manis

http://www.w3.org/2001/XMLSchema#string

J Zhang

http://www.w3.org/2001/XMLSchema#string

K J Seidl

http://www.w3.org/2001/XMLSchema#string

L Davidson

http://www.w3.org/2001/XMLSchema#string

P2860

Immunoglobulin class switching

Active anaphylaxis in IgE-deficient mice

Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development

A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development.

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans

Igf2 imprinting does not require its own DNA methylation or H19 RNA.

An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus

Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis.

Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.

P304

3000-3005

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.96.6.3000

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

96

http://www.w3.org/2001/XMLSchema#string

P577

1999-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

13212586

http://www.w3.org/2001/XMLSchema#string

P698

10077626

http://www.w3.org/2001/XMLSchema#string

P932

15884

http://www.w3.org/2001/XMLSchema#string