A nuclear matrix attachment site in the 4q35 locus has an enhancer-blocking activity in vivo: implications for the facio-scapulo-humeral dystrophy.
about
DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferationFacioscapulohumeral dystrophy: the path to consensus on pathophysiologyFacioscapulohumeral muscular dystrophy: consequences of chromatin relaxationAutosomal-dominant distal myopathy associated with a recurrent missense mutation in the gene encoding the nuclear matrix protein, matrin 3The Genome Conformation As an Integrator of Multi-Omic Data: The Example of Damage Spreading in CancerA functional role for 4qA/B in the structural rearrangement of the 4q35 region and in the regulation of FRG1 and ANT1 in facioscapulohumeral dystrophy.Hypermethylation of genomic 3.3-kb repeats is frequent event in HPV-positive cervical cancer.Myogenic enhancers regulate expression of the facioscapulohumeral muscular dystrophy-associated DUX4 gene.Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1.Myoblasts from affected and non-affected FSHD muscles exhibit morphological differentiation defectsDNA polymorphism and epigenetic marks modulate the affinity of a scaffold/matrix attachment region to the nuclear matrix.Asymmetric bidirectional transcription from the FSHD-causing D4Z4 array modulates DUX4 production.Comprehensive expression analysis of FSHD candidate genes at the mRNA and protein level.Simultaneous miRNA and mRNA transcriptome profiling of human myoblasts reveals a novel set of myogenic differentiation-associated miRNAs and their target genes.DUX4 promotes transcription of FRG2 by directly activating its promoter in facioscapulohumeral muscular dystrophyFacioscapulohumeral muscular dystrophy as a model for epigenetic regulation and diseaseThe Krüppel-like factor 15 as a molecular link between myogenic factors and a chromosome 4q transcriptional enhancer implicated in facioscapulohumeral dystrophy.ZNF555 protein binds to transcriptional activator site of 4qA allele and ANT1: potential implication in Facioscapulohumeral dystrophyEpigenetic mechanisms of facioscapulohumeral muscular dystrophy.DUX4 expression in FSHD muscle cells: how could such a rare protein cause a myopathy?Identification of a perinuclear positioning element in human subtelomeres that requires A-type lamins and CTCF.Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients.Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes.Chromatin conformation signatures: ideal human disease biomarkers?The cell biology of disease: FSHD: copy number variations on the theme of muscular dystrophyFacioscapulohumeral muscular dystrophy (FSHD): an enigma unravelled?In junk we trust: repetitive DNA, epigenetics and facioscapulohumeral muscular dystrophy.Eukaryotic enhancers: common features, regulation, and participation in diseases.How computer science can help in understanding the 3D genome architecture.3D genomics imposes evolution of the domain model of eukaryotic genome organization.Loop domain organization of the p53 locus in normal and breast cancer cells correlates with the transcriptional status of the TP53 and the neighboring genes.Kinetics and epigenetics of retroviral silencing in mouse embryonic stem cells defined by deletion of the D4Z4 element.D4Z4 as a prototype of CTCF and lamins-dependent insulator in human cells.Correction of the FSHD myoblast differentiation defect by fusion with healthy myoblasts.Facioscapulohumeral Muscular Dystrophy.
P2860
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P2860
A nuclear matrix attachment site in the 4q35 locus has an enhancer-blocking activity in vivo: implications for the facio-scapulo-humeral dystrophy.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
A nuclear matrix attachment si ...... cio-scapulo-humeral dystrophy.
@ast
A nuclear matrix attachment si ...... cio-scapulo-humeral dystrophy.
@en
type
label
A nuclear matrix attachment si ...... cio-scapulo-humeral dystrophy.
@ast
A nuclear matrix attachment si ...... cio-scapulo-humeral dystrophy.
@en
prefLabel
A nuclear matrix attachment si ...... cio-scapulo-humeral dystrophy.
@ast
A nuclear matrix attachment si ...... cio-scapulo-humeral dystrophy.
@en
P2093
P2860
P356
P1433
P1476
A nuclear matrix attachment si ...... cio-scapulo-humeral dystrophy.
@en
P2093
Andrei Petrov
Dalila Laoudj
Jeanne Allinne
Marc Lipinski
P2860
P356
10.1101/GR.6620908
P577
2007-11-21T00:00:00Z