HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation
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Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.Regain control of p53: Targeting leukemia stem cells by isoform-specific HDAC inhibitionHDAC8 Inhibition Blocks SMC3 Deacetylation and Delays Cell Cycle Progression without Affecting Cohesin-dependent Transcription in MCF7 Cancer Cells.Targeting binding partners of the CBFβ-SMMHC fusion protein for the treatment of inversion 16 acute myeloid leukemia.Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases.CBFβ-SMMHC creates aberrant megakaryocyte-erythroid progenitors prone to leukemia initiation in mice.The Novel HDAC8 Inhibitor WK2-16 Attenuates Lipopolysaccharide-Activated Matrix Metalloproteinase-9 Expression in Human Monocytic Cells and Improves Hypercytokinemia In Vivo.Structure-Based Identification of HDAC8 Non-histone SubstratesHDAC8 Prevents Anthrax Lethal Toxin-induced Cell Cycle Arrest through Silencing PTEN in Human Monocytic THP-1 Cells.Histone deacetylase inhibitors as cancer therapeutics.CHD7 deficiency delays leukemogenesis in mice induced by CBFB-MYH11.Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy.Structure-activity relationships of hydroxamate-based histone deacetylase-8 inhibitors: reality behind anticancer drug discovery.HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity.Novel histone deacetylase 8-selective inhibitor 1,3,4-oxadiazole-alanine hybrid induces apoptosis in breast cancer cells.The assembly competence domain is essential for inv(16)-associated acute myeloid leukemia.Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia.The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition.
P2860
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P2860
HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation
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2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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name
HDAC8 Inhibition Specifically ...... s by Restoring p53 Acetylation
@ast
HDAC8 Inhibition Specifically ...... s by Restoring p53 Acetylation
@en
type
label
HDAC8 Inhibition Specifically ...... s by Restoring p53 Acetylation
@ast
HDAC8 Inhibition Specifically ...... s by Restoring p53 Acetylation
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prefLabel
HDAC8 Inhibition Specifically ...... s by Restoring p53 Acetylation
@ast
HDAC8 Inhibition Specifically ...... s by Restoring p53 Acetylation
@en
P2093
P2860
P50
P1433
P1476
HDAC8 Inhibition Specifically ...... s by Restoring p53 Acetylation
@en
P2093
Hongjun Liu
Ravi Bhatia
Shi-Wei Chao
Tinisha McDonald
Wei-Jan Huang
Wei-Kai Hua
P2860
P304
P356
10.1016/J.STEM.2015.08.004
P407
P577
2015-09-16T00:00:00Z