Intracellular signaling mechanisms of acetaminophen-induced liver cell death. - Wikidata - awgldk - TriplyDB

Intracellular signaling mechanisms of acetaminophen-induced liver cell death.

Intracellular signaling mechanisms of acetaminophen-induced liver cell death.

http://www.wikidata.org/entity/Q36263962

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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples Nitric oxide and peroxynitrite in health and disease Some in vitro/in vivo chemically-induced experimental models of liver oxidative stress in rats Mitophagy: mechanisms, pathophysiological roles, and analysis Drug-induced hepatotoxicity: metabolic, genetic and immunological basis Role of p62/SQSTM1 in liver physiology and pathogenesis Targeting autophagy for the treatment of liver diseases Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose Identification of early biomarkers during acetaminophen-induced hepatotoxicity by fourier transform infrared microspectroscopy SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity New therapeutic approach: diphenyl diselenide reduces mitochondrial dysfunction in acetaminophen-induced acute liver failure Personalized medicine in human space flight: using Omics based analyses to develop individualized countermeasures that enhance astronaut safety and performance TAMH: A Useful In Vitro Model for Assessing Hepatotoxic Mechanisms Reactions of electrophiles with nucleophilic thiolate sites: relevance to pathophysiological mechanisms and remediation An Agent-Based Model of a Hepatic Inflammatory Response to Salmonella: A Computational Study under a Large Set of Experimental Data Human bone marrow mesenchymal stem cell-derived hepatocytes improve the mouse liver after acute acetaminophen intoxication by preventing progress of injury.Gentiana manshurica Kitagawa prevents acetaminophen-induced acute hepatic injury in mice via inhibiting JNK/ERK MAPK pathway In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe.Methanol extract of Dicranopteris linearis L. leaves impedes acetaminophen-induced liver intoxication partly by enhancing the endogenous antioxidant system.Chronic intermittent hypoxia and acetaminophen induce synergistic liver injury in mice.Mechanisms of immune-mediated liver injury.Use of transcriptomics in understanding mechanisms of drug-induced toxicity c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.Differential regulation of mitogen-activated protein kinase pathways by acetaminophen and its nonhepatotoxic regioisomer 3'-hydroxyacetanilide in TAMH cells.Development of flexible-heteroarotinoids for kidney cancer Pathologic role of stressed-induced glucocorticoids in drug-induced liver injury in mice.Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes.Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity.Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes Hepatocyte death: a clear and present danger.Is nuclear factor erythroid 2-related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in mice?High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.Lessons from a BACE1 inhibitor trial: off-site but not off base.Understanding lactic acidosis in paracetamol (acetaminophen) poisoning.Acetaminophen induces human neuroblastoma cell death through NFKB activation.Aloe vera attenuated liver injury in mice with acetaminophen-induced hepatitis.

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P2860

Intracellular signaling mechanisms of acetaminophen-induced liver cell death.

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Intracellular signaling mechanisms of acetaminophen-induced liver cell death.

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Intracellular signaling mechanisms of acetaminophen-induced liver cell death.

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Intracellular signaling mechanisms of acetaminophen-induced liver cell death.

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Toxicological Sciences

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Intracellular signaling mechanisms of acetaminophen-induced liver cell death.

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Hartmut Jaeschke

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Mary Lynn Bajt

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P2860

Two distinct pathways leading to nuclear apoptosis

Mechanisms of hepatotoxicity

AASLD position paper: the management of acute liver failure

Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: correlation of nuclear Ca2+ accumulation and early DNA fragmentation with cell death

Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress

Alkylation of the liver plasma membrane and inhibition of the Ca2+ ATPase by acetaminophen.

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry.

Liver regeneration.

Tissue repair: an important determinant of final outcome of toxicant-induced injury.

BCL-2 family: regulators of cell death.

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31-41

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