Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. - Wikidata - awgldk - TriplyDB

Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression.

Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression.

http://www.wikidata.org/entity/Q36266492

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Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetes Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2 Role of ceramide in diabetes mellitus: evidence and mechanisms.Myocardial triglyceride content at 3 T cardiovascular magnetic resonance and left ventricular systolic function: a cross-sectional study in patients hospitalized with acute heart failure.Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice.T cells cooperate with palmitic acid in induction of beta cell apoptosis.Enhanced exercise-induced muscle damage and muscle protein degradation in streptozotocin-induced type 2 diabetic rats.Long-chain acyl-CoA synthetases and fatty acid channeling PPARGC1A rs3736265 G>A polymorphism is associated with decreased risk of type 2 diabetes mellitus and fasting plasma glucose level Leptin: a multifunctional hormone.Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats.Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets Cytokines in the Progression of Pancreatic β-Cell Dysfunction Insulin resistance and beta-cell function--a clinical perspective.Protective Effects of Oleic Acid Against Palmitic Acid-Induced Apoptosis in Pancreatic AR42J Cells and Its Mechanisms.Linoleic acid stimulates [Ca2+]i increase in rat pancreatic beta-cells through both membrane receptor- and intracellular metabolite-mediated pathways.Islet beta cell failure in type 2 diabetes Triglyceride accumulation protects against fatty acid-induced lipotoxicity.Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance.Growth hormone receptor antagonist transgenic mice are protected from hyperinsulinemia and glucose intolerance despite obesity when placed on a HF diet.Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications.Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats.Regulation of glucose and lipid homeostasis by adiponectin: effects on hepatocytes, pancreatic β cells and adipocytes A simple matter of life and death-the trials of postnatal Beta-cell mass regulation Therapeutic perspectives of adipocytokines.Caspase induction and BCL2 inhibition in human adipose tissue: a potential relationship with insulin signaling alteration Ectopic fat deposition in prediabetic overweight and obese minority adolescents.Beta cells in type 2 diabetes - a crucial contribution to pathogenesis.Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials Leptin signaling in brain: A link between nutrition and cognition?Regulation of fatty acid homeostasis in cells: novel role of leptin.Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine.Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer.Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity.Nanospaces between endoplasmic reticulum and mitochondria as control centres of pancreatic β-cell metabolism and survival.

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P2860

Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression.

http://www.wikidata.org/entity/Q36266492

description

1998 nî lūn-bûn

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1998年の論文

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年學術文章

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1998年學術文章

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1998年學術文章

@zh-hant

name

Protection against lipoapoptos ...... intenance of Bcl-2 expression.

@ast

Protection against lipoapoptos ...... intenance of Bcl-2 expression.

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type

label

Protection against lipoapoptos ...... intenance of Bcl-2 expression.

@ast

Protection against lipoapoptos ...... intenance of Bcl-2 expression.

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prefLabel

Protection against lipoapoptos ...... intenance of Bcl-2 expression.

@ast

Protection against lipoapoptos ...... intenance of Bcl-2 expression.

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Protection against lipoapoptos ...... intenance of Bcl-2 expression.

@en

P2093

C B Newgard

http://www.w3.org/2001/XMLSchema#string

M Shimabukuro

http://www.w3.org/2001/XMLSchema#string

M Y Wang

http://www.w3.org/2001/XMLSchema#string

R H Unger

http://www.w3.org/2001/XMLSchema#string

Y T Zhou

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P2860

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

Apoptosis in the pathogenesis and treatment of disease

Leptin: the tale of an obesity gene.

OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype.

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.

Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

Bcl-2 and the regulation of programmed cell death.

Role of nitric oxide in obesity-induced beta cell disease.

Substitution at codon 269 (glutamine --> proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat.

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9558-9561

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9689119

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21377

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