Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells
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DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell deathA novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's diseaseExtracellular dopamine potentiates mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegansPKCδ sensitizes neuroblastoma cells to L-buthionine-sulfoximine and etoposide inducing reactive oxygen species overproduction and DNA damageNeuronal nitric oxide synthase and NADPH oxidase interact to affect cognitive, affective, and social behaviors in mice.NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's diseaseExercise protects against MPTP-induced neurotoxicity in mice.Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.Oxidative toxicity in neurodegenerative diseases: role of mitochondrial dysfunction and therapeutic strategies.Sanguisorbae radix protects against 6-hydroxydopamine-induced neurotoxicity by regulating NADPH oxidase and NF-E2-related factor-2/heme oxygenase-1 expressions.Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+) treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade.Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease.Mechanism of oxidative stress in neurodegeneration.NADPH oxidases: novel therapeutic targets for neurodegenerative diseasesAnti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease.Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease.The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease.Botanical phenolics and brain healthMitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes.The neuroprotective effects of apocynin.Oxidative stress in genetic mouse models of Parkinson's disease.Vitamin D and Parkinson's disease.The beneficial role of thiamine in Parkinson disease.The role of β-adrenergic blockers in Parkinson's disease: possible genetic and cell-signaling mechanisms.Calpain inhibition protected spinal cord motoneurons against 1-methyl-4-phenylpyridinium ion and rotenone.Respiratory syncytial virus (RSV) entry is inhibited by serine protease inhibitor AEBSF when present during an early stage of infection.Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy.Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.ω-3 fatty acid eicosapentaenoic acid attenuates MPP+-induced neurodegeneration in fully differentiated human SH-SY5Y and primary mesencephalic cells.Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation.DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection.Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line.Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro.Calpain plays a central role in 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in cerebellar granule neurons.The role of NADPH oxidase 1-derived reactive oxygen species in paraquat-mediated dopaminergic cell death.PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death.NOX Inhibitors - A Promising Avenue for Ischemic Stroke.Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease.Electroacupuncture Promotes Recovery of Motor Function and Reduces Dopaminergic Neuron Degeneration in Rodent Models of Parkinson's Disease.A time course of NADPH-oxidase up-regulation and endothelial nitric oxide synthase activation in the hippocampus following neurotrauma.
P2860
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P2860
Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Pharmacological inhibition of ...... ic dopaminergic neuronal cells
@ast
Pharmacological inhibition of ...... ic dopaminergic neuronal cells
@en
type
label
Pharmacological inhibition of ...... ic dopaminergic neuronal cells
@ast
Pharmacological inhibition of ...... ic dopaminergic neuronal cells
@en
prefLabel
Pharmacological inhibition of ...... ic dopaminergic neuronal cells
@ast
Pharmacological inhibition of ...... ic dopaminergic neuronal cells
@en
P2093
P2860
P1433
P1476
Pharmacological inhibition of ...... ic dopaminergic neuronal cells
@en
P2093
Anumantha G Kanthasamy
Arthi Kanthasamy
Chunjuan Song
Siddharth Kaul
Vellareddy Anantharam
P2860
P304
P356
10.1016/J.NEURO.2007.08.008
P577
2007-08-25T00:00:00Z