PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. - Wikidata - awgldk - TriplyDB

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death.

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death.

http://www.wikidata.org/entity/Q39873016

about

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update NCLX is an essential component of mitochondrial Na+/Ca2+ exchange PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy PINK1 cleavage at position A103 by the mitochondrial protease PARL.Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer The Dual Function of Reactive Oxygen/Nitrogen Species in Bioenergetics and Cell Death: The Role of ATP Synthase Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation Barth Syndrome: From Mitochondrial Dysfunctions Associated with Aberrant Production of Reactive Oxygen Species to Pluripotent Stem Cell Studies Modulation of the matrix redox signaling by mitochondrial Ca(2.)The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics Mitochondrial biology and Parkinson's disease Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease Mouse models of Parkinson's disease associated with mitochondrial dysfunction PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease Emerging modes of PINK1 signaling: another task for MARK2 Genetics of Parkinson's disease - a clinical perspective Mitochondrial permeability transition pore is a potential drug target for neurodegeneration Upstream deregulation of calcium signaling in Parkinson's disease PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila Tissue- and cell-specific mitochondrial defect in Parkin-deficient mice Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.High-resolution crystal structures of two crystal forms of human cyclophilin D in complex with PEG 400 molecules Investigating mitochondrial redox state using NADH and NADPH autofluorescence Parkinson's disease: animal models and dopaminergic cell vulnerability PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1 Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression Evidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1 Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy Gene-environment interactions: key to unraveling the mystery of Parkinson's disease Energy failure: does it contribute to neurodegeneration?Beyond mitophagy: cytosolic PINK1 as a messenger of mitochondrial health Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts Bioenergetic consequences of PINK1 mutations in Parkinson disease Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease

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P2860

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death.

http://www.wikidata.org/entity/Q39873016

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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2009年论文

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2009年论文

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name

PINK1-associated Parkinson's d ...... to calcium-induced cell death.

@en

PINK1-associated Parkinson's d ...... to calcium-induced cell death.

@nl

type

label

PINK1-associated Parkinson's d ...... to calcium-induced cell death.

@en

PINK1-associated Parkinson's d ...... to calcium-induced cell death.

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prefLabel

PINK1-associated Parkinson's d ...... to calcium-induced cell death.

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PINK1-associated Parkinson's d ...... to calcium-induced cell death.

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J.MOLCEL.2009.02.013

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PINK1-associated Parkinson's d ...... to calcium-induced cell death.

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Alison Wood-Kaczmar

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David S Latchman

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Emma Deas

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Helene Plun-Favreau

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Kristina Klupsch

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Sonia Gandhi

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Zhi Yao

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P2860

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

PINK1 protein in normal human brain and Parkinson's disease

Staging of brain pathology related to sporadic Parkinson's disease

Oxidative stress in neurodegeneration: cause or consequence?

'Rejuvenation' protects neurons in mouse models of Parkinson's disease

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

The mitochondrial permeability transition pore and its role in cell death

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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5

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33

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Sarah J. Tabrizi

Michael R. Duchen

Nicholas W. Wood

Andrey Y Abramov

Julian Downward

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2009-03-01T00:00:00Z

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24200541

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19285945

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Parkinson's disease

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2724101

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