Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts.
about
CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and DiseaseEngineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.Humanized hemato-lymphoid system miceThe complex and central role of interferon-γ in graft-versus-host disease and graft-versus-tumor activityOKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues.Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia.Co-expression of MET and CD47 is a novel prognosticator for survival of luminal breast cancer patientsNew strategies in acute myelogenous leukemia: leukemogenesis and personalized medicine.Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemiaMacrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk.Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cellsSpontaneous cell fusion of acute leukemia cells and macrophages observed in cells with leukemic potential.CD47-retargeted oncolytic adenovirus armed with melanoma differentiation-associated gene-7/interleukin-24 suppresses in vivo leukemia cell growthDurable antitumor responses to CD47 blockade require adaptive immune stimulation.Monocytes and macrophages in cancer: development and functionsCD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer.Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA RatsSIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells.Dendritic cell-based immunotherapy for myeloid leukemias.Understanding of leukemic stem cells and their clinical implications.Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies.Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses.Relevance of leukemic stem cells in acute myeloid leukemia: heterogeneity and influence on disease monitoring, prognosis and treatment design.Update on antigen-specific immunotherapy of acute myeloid leukemia.Cancer stem cells and tumor-associated macrophages: a roadmap for multitargeting strategies.Cancer stem cells: a potential target for cancer therapy.Antigen-specific immunotherapy for acute myeloid leukemia: where are we now, and where do we go from here?Therapeutically targeting SELF-reinforcing leukemic niches in acute myeloid leukemia: A worthy endeavor?Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner.CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-Infected Erythrocytes and Clearance of Malaria In Vivo.The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer.Hide-and-seek: the interplay between cancer stem cells and the immune system.Localized CD47 blockade enhances immunotherapy for murine melanoma.SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.Targeting SIRPα in cancer.Signal-regulatory protein α from the NOD mouse binds human CD47 with an exceptionally high affinity-- implications for engraftment of human cells"Stealth dissemination" of macrophage-tumor cell fusions cultured from blood of patients with pancreatic ductal adenocarcinoma.Signal regulatory protein α is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression.Targeting Leukemia Stem Cells in the Bone Marrow Niche.
P2860
Q21284814-63E3D537-805B-4A5D-A0E6-0E024F471AFFQ24605057-0D704F25-656E-4C74-9E4E-FE7E6FC9A636Q26771440-666EFA32-D789-43BB-9538-81ED88AAD1CDQ26851545-44046E57-1675-4297-8575-D25C60C67F56Q33749684-664251C9-483D-45E9-AE44-D23156A331C8Q34232877-F1C4D4EA-B70C-4462-B278-964B78C09379Q34483478-8F95C287-5F06-48C3-8313-AE8952F7BD89Q34715598-C91E27C6-66D1-46D8-B898-4090BE54F538Q35056301-A4C64A90-D646-4306-9B1C-E3D8B9B64E85Q35129097-493C7590-BC76-4194-8958-A25F9C5B7CDCQ36008395-C8228B77-751E-439A-A26F-B66205C63107Q36216038-4A0BB61B-2149-41CE-9F60-CD472C09007CQ36446447-C6F5E8D7-F47B-405E-B076-E4F4AB25FFB0Q36685435-716D8AFD-B31B-47E8-BD7E-27E344CCB226Q36904867-F58BDE83-D08F-4874-BB18-753DE915F200Q37028772-E8C04A26-A9E1-4D97-8928-9D1176626CEDQ37042256-45189F67-6A53-47B6-A205-3764871699D0Q37181472-E46912BC-43D7-4662-A66F-A0C4B2EBEFC4Q37322155-28E4A0BA-64B5-4B3A-B000-2B34AA042C58Q37420778-F648337C-AA65-408A-AD62-43E43C10731DQ37616010-E6832DAC-572B-43FE-86E4-13BE372FADD9Q37744822-A4EF7261-4189-44CD-93A9-D04272ABD8A3Q38218786-648BFD39-5E3A-409B-A4C3-BD286B5CBD8EQ38253011-48E27E1C-4178-4A4D-B5C1-05F724E255A2Q38432103-BB1ABE1F-20D1-4058-83BD-F4A602883AB6Q38472322-344E5264-E0F1-4CBD-9A7F-B87BD24B9C4FQ38476034-338F3BBF-0DAF-470A-A4B7-BE37F5449D54Q38700209-44F68C47-7A3B-4150-8CEC-7921504B2867Q38715325-1B6E1C76-3364-416D-9340-90AD3A888E92Q38759198-8344303A-5A2D-4466-AE91-BE4B3C2E8A50Q38885296-9333945C-104C-4E01-B523-C1A8F760508CQ38930113-E13D1155-51AA-424A-B089-6CBE59DCEB14Q39014465-B576E0F3-B13B-45F9-B684-2DDE21D38306Q40056852-CF4FC8FC-BD15-4BFC-8F60-3B88B96C53A9Q40244852-0F5068DD-24EA-4A7B-AB9C-840D5BFE0454Q41810660-17CBF3B4-A76B-4C3A-A898-11E5BF12126EQ42087251-8C61D8EE-C38D-461A-A66D-A8CC1047222EQ42366169-5DB98595-FD0A-4C4F-BD85-5FE0EA83E512Q51824352-CDA92AA2-27BD-4B60-B6D7-200DB809E00EQ52375473-8506BF90-0AE0-4DD7-8E10-E250796E7055
P2860
Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Disruption of SIRPα signaling ...... emia stem cells in xenografts.
@ast
Disruption of SIRPα signaling ...... emia stem cells in xenografts.
@en
type
label
Disruption of SIRPα signaling ...... emia stem cells in xenografts.
@ast
Disruption of SIRPα signaling ...... emia stem cells in xenografts.
@en
prefLabel
Disruption of SIRPα signaling ...... emia stem cells in xenografts.
@ast
Disruption of SIRPα signaling ...... emia stem cells in xenografts.
@en
P2093
P2860
P921
P356
P1476
Disruption of SIRPα signaling ...... emia stem cells in xenografts.
@en
P2093
Alexandre P A Theocharides
Andrei V Malko
Armando G Poeppl
Jayne S Danska
Jean C Y Wang
Jenny M Ho
Liqing Jin
Mark D Minden
Po-Yan Cheng
Tatiana K Prasolava
P2860
P304
P356
10.1084/JEM.20120502
P407
P577
2012-09-03T00:00:00Z