Bardoxolone methyl decreases megalin and activates nrf2 in the kidney. - Wikidata - awgldk - TriplyDB

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.

http://www.wikidata.org/entity/Q36280389

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Recent advances in understanding of chronic kidney disease Antioxidant resveratrol restores renal sodium transport regulation in SHR Citral is renoprotective for focal segmental glomerulosclerosis by inhibiting oxidative stress and apoptosis and activating Nrf2 pathway in mice Therapeutic decisions in multiple sclerosis: moving beyond efficacy The paradox of bardoxolone methyl: a call for every witness on the stand?Transcriptome-based analysis of kidney gene expression changes associated with diabetes in OVE26 mice, in the presence and absence of losartan treatment The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease.Is there a sweet spot for Nrf2 activation in the treatment of diabetic kidney disease?Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease.Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.Emerging drugs for chronic kidney disease.Bardoxolone Methyl Prevents Fat Deposition and Inflammation in Brown Adipose Tissue and Enhances Sympathetic Activity in Mice Fed a High-Fat Diet Brazilian green propolis water extract up-regulates the early expression level of HO-1 and accelerates Nrf2 after UVA irradiation.Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy.Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney.Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective The extinguished BEACON of bardoxolone: not a Monday morning quarterback story.Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease.The proximal tubule and albuminuria: really!Keap1 inhibition attenuates glomerulosclerosis.New therapeutic strategies under development to halt the progression of renal failure.Emerging role of post-translational modifications in chronic kidney disease and cardiovascular disease.Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression.The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.The endocytic receptor megalin and its associated proteins in proximal tubule epithelial cells.Genetic and Pharmacologic Targeting of Glycogen Synthase Kinase 3β Reinforces the Nrf2 Antioxidant Defense against Podocytopathy.Rationale and trial design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: the Occurrence of Renal Events (BEACON).New treatments for CKD--new insights into pathogenesis Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects.NRF2 PREVENTS HYPERTENSION, INCREASED ADMA, MICROVASCULAR OXIDATIVE STRESS AND DYSFUNCTION IN MICE WITH TWO WEEKS OF ANGIOTENSIN II INFUSION.Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone- and salt-induced renal injury.Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice.

P2860

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P2860

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.

http://www.wikidata.org/entity/Q36280389

description

2012 nî lūn-bûn

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2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

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2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh

2012年學術文章

@zh-hant

name

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.

@ast

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.

@en

type

label

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.

@ast

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.

@en

prefLabel

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.

@ast

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.

@en

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P1433

Journal of the American Society of Nephrology

P1476

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.

@en

P2093

Colin J Meyer

http://www.w3.org/2001/XMLSchema#string

Glenn M Chertow

http://www.w3.org/2001/XMLSchema#string

Keith W Ward

http://www.w3.org/2001/XMLSchema#string

Nosratola D Vaziri

http://www.w3.org/2001/XMLSchema#string

Scott A Reisman

http://www.w3.org/2001/XMLSchema#string

Sudarshan Hebbar

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P2860

Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin

New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress

Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B

Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress

Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury

Regulation of genes encoding NAD(P)H:quinone oxidoreductases.

The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge.

Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule.

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1663-1673

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10.1681/ASN.2012050457

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10

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22859857

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3458470

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