Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1. - Wikidata - awgldk - TriplyDB

Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

http://www.wikidata.org/entity/Q36280815

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Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer Persistent exposure to Mycoplasma induces malignant transformation of human prostate cells Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure Regulation of cell cycle by the anaphase spindle midzone Clinical Overview of MDM2/X-Targeted Therapies Links between mutant p53 and genomic instability Centrosomes, chromosome instability (CIN) and aneuploidy DNA damage associated with mitosis and cytokinesis failure Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.Tumor treating fields perturb the localization of septins and cause aberrant mitotic exit Quantitative analysis of cytokinesis in situ during C. elegans postembryonic development Functional Significance of Aurora Kinases-p53 Protein Family Interactions in Cancer Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53 Vascular smooth muscle polyploidization as a biomarker for aging and its impact on differential gene expression CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination SUMO-specific protease 2 in Mdm2-mediated regulation of p53 Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity p53 suppresses tetraploid development in mice The cellular geography of aurora kinases Triggering p53 after cytokinesis failure Cell division and cell survival in the absence of survivin.Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780 Persistent telomere damage induces bypass of mitosis and tetraploidy.Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention.TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres Failure of cell cleavage induces senescence in tetraploid primary cells.p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis.Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.

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P2860

Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

http://www.wikidata.org/entity/Q36280815

description

2001 nî lūn-bûn

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2001年の論文

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2001年学术文章

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2001年學術文章

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2001年學術文章

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2001年學術文章

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name

Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

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Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

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type

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Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

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Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

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Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

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Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

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Molecular Biology of the Cell

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Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

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Andreassen PR

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Lacroix FB

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Lohez OD

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Margolis RL

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P2860

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Mutations of mitotic checkpoint genes in human cancers

Genetic instability of cancer cells is proportional to their degree of aneuploidy

Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery

WAF1, a potential mediator of p53 tumor suppression

Genetic instabilities in human cancers

Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

Enhanced phosphorylation of p53 by ATM in response to DNA damage

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10.1091/MBC.12.5.1315

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12

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34586

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