Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity
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Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.Proper protein glycosylation promotes mitogen-activated protein kinase signal fidelityDynamic single cell measurements of kinase activity by synthetic kinase activity relocation sensorsData-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states.A single mechanism can explain network-wide insulin resistance in adipocytes from obese patients with type 2 diabetes.A generalised enzyme kinetic model for predicting the behaviour of complex biochemical systemsPheromone-induced morphogenesis and gradient tracking are dependent on the MAPK Fus3 binding to Gα.Signal inhibition by a dynamically regulated pool of monophosphorylated MAPK.Mathematical modeling reveals differential regulation of MAPK activity by phosphatase proteins in the yeast pheromone response pathway.Mitogen-activated protein kinase (MAPK) dynamics determine cell fate in the yeast mating response.Analysis of the thresholds for transcriptional activation by the yeast MAP kinases Fus3 and Kss1.Variable Dependence of Signaling Output on Agonist Occupancy of Ste2p, a G Protein-coupled Receptor in Yeast.
P2860
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P2860
Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年學術文章
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2012年學術文章
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2012年學術文章
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name
Combined computational and exp ...... nism for signaling specificity
@ast
Combined computational and exp ...... nism for signaling specificity
@en
type
label
Combined computational and exp ...... nism for signaling specificity
@ast
Combined computational and exp ...... nism for signaling specificity
@en
prefLabel
Combined computational and exp ...... nism for signaling specificity
@ast
Combined computational and exp ...... nism for signaling specificity
@en
P2093
P2860
P356
P1476
Combined computational and exp ...... nism for signaling specificity
@en
P2093
Beverly Errede
Henrik G Dohlman
Michal J Nagiec
Necmettin Yildirim
Stephen C Parnell
Timothy C Elston
P2860
P304
P356
10.1091/MBC.E12-04-0333
P50
P577
2012-08-08T00:00:00Z