Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts.
about
Connexin46 mutations in autosomal dominant congenital cataract.Properties of gap junction channels formed by Cx46 alone and in combination with Cx50.Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasiaFunctional role of the carboxyl terminal domain of human connexin 50 in gap junctional channelsA novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataractTargeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formationLens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)Gap junctionsThe role of Eph receptors in lens function and diseaseFunctional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesionAssembly of the cochlear gap junction macromolecular complex requires connexin 26.Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataractNovel distribution of junctional adhesion molecule-C in the neural retina and retinal pigment epitheliumDevelopment of a 3D finite element model of lens microcirculationUpregulation and maintenance of gap junctional communication in lens cellsDissection of the molecular basis of pp60(v-src) induced gating of connexin 43 gap junction channels.Transgenic overexpression of connexin50 induces cataracts.Two tyrosine-based sorting signals in the Cx43 C-terminus cooperate to mediate gap junction endocytosis.Connexin 48.5 is required for normal cardiovascular function and lens development in zebrafish embryos.Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse.A novel connexin 50 (GJA8) mutation in a Chinese family with a dominant congenital pulverulent nuclear cataract.Mouse lens connexin23 (Gje1) does not form functional gap junction channels but causes enhanced ATP release from HeLa cellsGlobal gene expression analysis of lenses from different mouse strains and in the alpha3Cx46 knockout mouse.Cx46 hemichannels contribute to the sodium leak conductance in lens fiber cellsConnexin32 in the peripheral nervous system. Functional analysis of mutations associated with X-linked Charcot-Marie-Tooth syndrome and implications for the pathophysiology of the disease.Homeostasis in the vertebrate lens: mechanisms of solute exchange.Regulation of lens gap junctions by Transforming Growth Factor beta.Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis.The molecular basis of selective permeability of connexins is complex and includes both size and charge.Amino acid residue Val362 plays a critical role in maintaining the structure of C terminus of connexin 50 and in lens epithelial-fiber differentiationGap junctions and blood-tissue barriersA genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14.Gap junctions.A novel mutation in GJA8 causing congenital cataract-microcornea syndrome in a Chinese pedigree.Connexin mediated cataract prevention in miceUSH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses.The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctions.Hemichannel and junctional properties of connexin 50.Exchange of gating properties between rat cx46 and chicken cx45.6.Cat-Map: putting cataract on the map
P2860
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P2860
Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Targeted ablation of connexin5 ...... zonular pulverulent cataracts.
@ast
Targeted ablation of connexin5 ...... zonular pulverulent cataracts.
@en
type
label
Targeted ablation of connexin5 ...... zonular pulverulent cataracts.
@ast
Targeted ablation of connexin5 ...... zonular pulverulent cataracts.
@en
prefLabel
Targeted ablation of connexin5 ...... zonular pulverulent cataracts.
@ast
Targeted ablation of connexin5 ...... zonular pulverulent cataracts.
@en
P2860
P356
P1476
Targeted ablation of connexin5 ...... zonular pulverulent cataracts
@en
P2093
D A Goodenough
P2860
P304
P356
10.1083/JCB.143.3.815
P407
P577
1998-11-01T00:00:00Z