DNA precursor pool: a significant target for N-methyl-N-nitrosourea in C3H/10T1/2 clone 8 cells - Wikidata - awgldk - TriplyDB

DNA precursor pool: a significant target for N-methyl-N-nitrosourea in C3H/10T1/2 clone 8 cells

DNA precursor pool: a significant target for N-methyl-N-nitrosourea in C3H/10T1/2 clone 8 cells

http://www.wikidata.org/entity/Q36289311

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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2 Chemical carcinogens: a review of the science and its associated principles. U.S. Interagency Staff Group on Carcinogens Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival MTH1 Substrate Recognition--An Example of Specific Promiscuity.Chemicals, cancer and cancer biology Capturing a mammalian DNA polymerase extending from an oxidized nucleotide.Validation and development of MTH1 inhibitors for treatment of cancer.Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity.Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide Misincorporation during DNA synthesis, analyzed by gel electrophoresis.Mutagenesis of bacteriophage T7 in vitro by incorporation of O6-methylguanine during DNA synthesis.Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1.Reprint of "Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair".Oxidized nucleotide insertion by pol β confounds ligation during base excision repair.Deoxyribonucleotide metabolism, mutagenesis and cancer.Do carcinogen-modified deoxynucleotide precursors contribute to cellular mutagenesis?Exploiting DNA repair defects for novel cancer therapies.TH588, an MTH1 inhibitor, enhances phenethyl isothiocyanate-induced growth inhibition in pancreatic cancer cells.Imbalance of deoxyribonucleoside triphosphates and DNA double-strand breaks in mouse mammary tumor FM3A cells treated in vitro with an antineoplastic tropolone derivative.Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors.Cancer: Damage prevention targeted.MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP

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DNA precursor pool: a significant target for N-methyl-N-nitrosourea in C3H/10T1/2 clone 8 cells

http://www.wikidata.org/entity/Q36289311

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1982 nî lūn-bûn

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1982年の論文

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1982年学术文章

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1982年学术文章

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1982年学术文章

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1982年学术文章

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1982年学术文章

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1982年學術文章

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1982年學術文章

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Proceedings of the National Academy of Sciences of the United States of America

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DNA precursor pool: a signific ...... ea in C3H/10T1/2 clone 8 cells

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M D Topal

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M S Baker

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Selective silencing of eukaryotic DNA.

Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.

Depurination causes mutations in SOS-induced cells.

The molecular electrostatic potential of the B-DNA helix. VI. The regions of the base pairs in poly (dG.dC) and poly (dA.dT).

Cycle-related toxicity and transformation in 10T1/2 cells treated with N-methyl-N'-nitro-N-nitrosoguanidine

Cell cycle-specific mutagenesis at the hypoxanthine phosphoribosyltransferase locus in adult rat liver epithelial cells.

The enzymatic release of O6-methylguanine and 3-methyladenine from DNA reacted with the carcinogen N-methyl-N-nitrosourea

Ultraviolet reactivation of herpes simplex virus is mutagenic and inducible in mammlian cells.

Restriction and modification of DNA.

Analysis of nucleotide pools in animal cells.

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2211-2215

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10.1073/PNAS.79.7.2211

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1982-04-01T00:00:00Z

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16243569

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6954535

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346161

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