Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface. - Wikidata - awgldk - TriplyDB

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface.

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface.

http://www.wikidata.org/entity/Q36290338

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Desmosomes in acquired disease Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease Mechanistic basis of desmosome-targeted diseases Mechanisms of Autoantibody-Induced Pathology.Coherent somatic mutation in autoimmune disease.Pemphigus vulgaris autoantibody profiling by proteomic technique.Persistence of anti-desmoglein 3 IgG(+) B-cell clones in pemphigus patients over years.Pathophysiology of T follicular helper cells in humans and mice Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis.Overlapping IgG4 Responses to Self- and Environmental Antigens in Endemic Pemphigus Foliaceus.Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies in Pemphigus Vulgaris Super-Resolution Microscopy Reveals Altered Desmosomal Protein Organization in Tissue from Patients with Pemphigus Vulgaris.Characterization of pathogenic human monoclonal autoantibodies against GM-CSF.MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4.Proteomic Analysis of Pemphigus Autoantibodies Indicates a Larger, More Diverse, and More Dynamic Repertoire than Determined by B Cell Genetics.Rituximab therapy in pemphigus and other autoantibody-mediated diseases.Setting the target for pemphigus vulgaris therapy.The role of somatic hypermutation in the generation of pathogenic antibodies in SLE.Autoreactive T cells in the immune pathogenesis of pemphigus vulgaris.Desmosomal cadherins and signaling: lessons from autoimmune disease.Desmosomes and extradesmosomal adhesive signaling contacts in pemphigus.Report of the joint ESOT and TTS basic science meeting 2013: current concepts and discoveries in translational transplantation.Mitochondrial dysfunction: a neglected component of skin diseases.Noise in multiple sclerosis: unwanted and necessary.Plakophilin-1 protects keratinocytes from pemphigus vulgaris IgG by forming calcium-independent desmosomes Immune response in pemphigus and beyond: progresses and emerging concepts.Mechanisms of Disease: Pemphigus and Bullous Pemphigoid.Germinal centers and autoimmune disease in humans and mice.Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus.Inhibition of JNK in HaCaT cells induced tight junction formation with decreased expression of cytokeratin 5, cytokeratin 17 and desmoglein 3.Autoantibodies in chronic inflammatory neuropathies: diagnostic and therapeutic implications.Nuclear magnetic resonance titration of the interaction between pemphigus vulgaris autoantibodies and REWVKFAKPCRE, a therapeutic desmoglein 3 peptide.Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering.Crosstalk between Signaling Pathways in Pemphigus: A Role for Endoplasmic Reticulum Stress in p38 Mitogen-Activated Protein Kinase Activation?AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies Shared VH1-46 gene usage by pemphigus vulgaris autoantibodies indicates common humoral immune responses among patients.Pemphigus: a Comprehensive Review on Pathogenesis, Clinical Presentation and Novel Therapeutic Approaches.IgG4-mediated autoimmune diseases: a niche of antibody-mediated disorders.Dissecting human antibody responses: useful, basic and surprising findings.

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P2860

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface.

http://www.wikidata.org/entity/Q36290338

description

2012 nî lūn-bûn

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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Pemphigus autoantibodies gener ...... the desmoglein-3 cis-interface

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Anna Sinistro

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Antonio Lanzavecchia

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Biagio Didona

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Bungo Ohyama

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Davide Corti

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Fabrizia Vanzetta

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Federica Sallusto

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Giovanna Zambruno

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Giuseppe Cianchini

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Jerry Sloostra

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P2860

Activation of Virus-specific Memory B Cells in the Absence of T Cell Help

C-cadherin ectodomain structure and implications for cell adhesion mechanisms

Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion

Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism

Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display.

IMGT, the international ImMunoGeneTics information system.

The evolution of human anti-double-stranded DNA autoantibodies

Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus

Homologous regions of autoantibody heavy chain complementarity-determining region 3 (H-CDR3) in patients with pemphigus cause pathogenicity

Correlation of peptide specificity and IgG subclass with pathogenic and nonpathogenic autoantibodies in pemphigus vulgaris: a model for autoimmunity

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10.1172/JCI64413

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10

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122

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Takashi Hashimoto

Masayuki Amagai

Giovanni Di Zenzo

Giulia Di Lullo

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2012-09-04T00:00:00Z

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22996451

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