Extracellular matrix regulates apoptosis in mammary epithelium through a control on insulin signaling
about
Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagementInsulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function.Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation.Active stromelysin-3 (MMP-11) increases MCF-7 survival in three-dimensional Matrigel culture via activation of p42/p44 MAP-kinaseLaminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathwaysNischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migrationReduction of decoy receptor 3 enhances TRAIL-mediated apoptosis in pancreatic cancerProliferation and apoptosis in mammary epithelium during the rat oestrous cycleThe ?5?1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitroRac1 is essential for basement membrane-dependent epiblast survivalIntegrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis.IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients.Integrins in development and cancer.Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression.The dominance of the microenvironment in breast and ovarian cancer.alpha5beta1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol 3-kinase and protein kinase B-dependent pathwayEffect of antibodies on endothelium.Role of the tumor microenvironment in mediating de novo resistance to drugs and physiological mediators of cell death.Apoptosis regulation in the mammary gland.p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKBExtracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix.Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization.The extracellular matrix as an adhesion checkpoint for mammary epithelial function.The RhoA-Rok-myosin II pathway is involved in extracellular matrix-mediated regulation of prolactin signaling in mammary epithelial cells.Serotoninergic and Circadian Systems: Driving Mammary Gland Development and Function.Integrins and cell-fate determination.Involvement of insulin receptor substrate 2 in mammary tumor metastasis.Differentiation of Human Induced Pluripotent Stem Cells to Mammary-like Organoids.Rodent animal models: from mild to advanced stages of diabetic nephropathy.Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I.Loss of anchorage primarily induces non-apoptotic cell death in a human mammary epithelial cell line under atypical focal adhesion kinase signaling.Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment.Biosynthesized matrix provides a key role for survival signaling in bronchial epithelial cells.Early events in the anoikis program occur in the absence of caspase activation.Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, phosphatidylinositol 3-kinase and extracellular signal regulated kinases.Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor.Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cellsRegulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines.Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling.Antibody against integrin lymphocyte function-associated antigen 1 inhibits HIV type 1 infection in primary cells through caspase-8-mediated apoptosis.
P2860
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P2860
Extracellular matrix regulates apoptosis in mammary epithelium through a control on insulin signaling
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Extracellular matrix regulates ...... a control on insulin signaling
@ast
Extracellular matrix regulates ...... a control on insulin signaling
@en
type
label
Extracellular matrix regulates ...... a control on insulin signaling
@ast
Extracellular matrix regulates ...... a control on insulin signaling
@en
prefLabel
Extracellular matrix regulates ...... a control on insulin signaling
@ast
Extracellular matrix regulates ...... a control on insulin signaling
@en
P2093
P2860
P921
P356
P1476
Extracellular matrix regulates ...... a control on insulin signaling
@en
P2093
P2860
P304
P356
10.1083/JCB.144.6.1337
P407
P577
1999-03-01T00:00:00Z