Mechanism by which caffeine potentiates lethality of nitrogen mustard
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Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrestHuman immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustardCloning and sequence analysis of the Saccharomyces cerevisiae RAD9 gene and further evidence that its product is required for cell cycle arrest induced by DNA damageCaffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activityThe cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial designThe radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathwayp53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaksPhysical and functional interactions between Lyn and p34cdc2 kinases in irradiated human B-cell precursors.Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override.Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.Caffeine inhibits human immunodeficiency virus type 1 transduction of nondividing cellsDDB1 maintains genome integrity through regulation of Cdt1Cell cycle control, checkpoint mechanisms, and genotoxic stress.The enigmatic effects of caffeine in cell cycle and cancerDNA damage during G2 phase does not affect cell cycle progression of the green alga Scenedesmus quadricaudaPhenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector.Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibitionSelective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer.Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumorsCaffeine potentiates the lethality of tumour necrosis factor in cancer cells.DNA index of ovarian carcinomas from 56 patients: in vivo in vitro studies.AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylationNew opportunities in chemosensitization and radiosensitization: modulating the DNA-damage response.Caffeine overcomes a restriction point associated with DNA replication, but does not accelerate mitosis.Apoptosis. Biochemical events and relevance to cancer chemotherapy.DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.Structure-activity relationships for G2 checkpoint inhibition by caffeine analogs.Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage.UV-B-induced cell cycle perturbations, micronucleus induction, and modulation by caffeine in human keratinocytes.2-Aminopurine overrides multiple cell cycle checkpoints in BHK cells.v-Src Causes Chromosome Bridges in a Caffeine-Sensitive Manner by Generating DNA DamageG2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancerWild-type p53 is a cell cycle checkpoint determinant following irradiationChemically induced premature mitosis: differential response in rodent and human cells and the relationship to cyclin B synthesis and p34cdc2/cyclin B complex formation.Targeting DNA repair and the cell cycle in glioblastoma.Therapeutic potential of investigational CHK-1 inhibitors for the treatment of solid tumors.Tousled-like kinase 2 regulates recovery from a DNA damage-induced G2 arrest.Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro.Antiproliferation effect of commercially brewed coffees on human ovarian cancer cells in vitro.Thioredoxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest.
P2860
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P2860
Mechanism by which caffeine potentiates lethality of nitrogen mustard
description
1982 nî lūn-bûn
@nan
1982年の論文
@ja
1982年学术文章
@wuu
1982年学术文章
@zh-cn
1982年学术文章
@zh-hans
1982年学术文章
@zh-my
1982年学术文章
@zh-sg
1982年學術文章
@yue
1982年學術文章
@zh
1982年學術文章
@zh-hant
name
Mechanism by which caffeine potentiates lethality of nitrogen mustard
@ast
Mechanism by which caffeine potentiates lethality of nitrogen mustard
@en
type
label
Mechanism by which caffeine potentiates lethality of nitrogen mustard
@ast
Mechanism by which caffeine potentiates lethality of nitrogen mustard
@en
prefLabel
Mechanism by which caffeine potentiates lethality of nitrogen mustard
@ast
Mechanism by which caffeine potentiates lethality of nitrogen mustard
@en
P2860
P356
P1476
Mechanism by which caffeine potentiates lethality of nitrogen mustard
@en
P2093
P2860
P304
P356
10.1073/PNAS.79.9.2942
P407
P577
1982-05-01T00:00:00Z