Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.
about
Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavageStructural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac SulfideAPLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatmentγ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein ProductionDevelopment and mechanism of γ-secretase modulators for Alzheimer's disease.Biological function of Presenilin and its role in AD pathogenesisComplex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulatorsInitial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene GlycosideCombining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production.
P2860
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P2860
Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.
description
2012 nî lūn-bûn
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2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
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2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
Second generation γ-secretase ...... of Notch β and Aβ production.
@ast
Second generation γ-secretase ...... of Notch β and Aβ production.
@en
type
label
Second generation γ-secretase ...... of Notch β and Aβ production.
@ast
Second generation γ-secretase ...... of Notch β and Aβ production.
@en
prefLabel
Second generation γ-secretase ...... of Notch β and Aβ production.
@ast
Second generation γ-secretase ...... of Notch β and Aβ production.
@en
P2093
P2860
P50
P356
P1476
Second generation γ-secretase ...... of Notch β and Aβ production.
@en
P2093
Anders Juréus
Jan Ottervald
Jenny Blomqvist
Johan Lundkvist
Johanna Wanngren
Kia Strömberg
Rebecka Klintenberg
Santiago Parpal
Susanne Rosqvist
Tomas Borgegård
P2860
P304
32640-32650
P356
10.1074/JBC.M112.376541
P407
P577
2012-07-31T00:00:00Z