about
A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.Generalized potential of adult neural stem cellsChanged membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranesThe large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.Notch receptor cleavage depends on but is not directly executed by presenilins.Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on γ-secretase.Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.Variable phenotype of Alzheimer's disease with spastic paraparesis.Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease.Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.A sensitive and quantitative assay for measuring cleavage of presenilin substrates.Presenilin dependence of phospholipase C and protein kinase C signaling.Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis.Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype.Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene.Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression.Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.No association of spastic paraparesis genes in PSEN1 Alzheimer's disease with spastic paraparesis.Generation and phenotypic characterization of a galanin overexpressing mouse
P50
Q24544042-FCCA93C9-DE76-4227-9448-BA5BDDCEA779Q28145509-118BD8DF-EA7F-40D5-AAE1-159DE9DD48D6Q30363483-AF6057D0-E6F9-42E4-BDFA-ED77AD1F69CAQ33545253-4EE14786-64E2-4DB2-99CD-554C240B444AQ33726342-2A46EB6E-D335-45C6-A41E-BFD55F234825Q34021542-A7AE79DF-4BD4-4FD1-BB23-BC61188B895FQ34744950-AFA7526F-B046-4073-AC9B-36B585831494Q36294856-6CAB2FD0-07F4-4C3F-AAB0-D480F4C05F12Q36998026-8726B2FE-8BAB-4600-8A67-0B4341A0A7FEQ38418887-58464338-8882-4C80-9332-6C94A134AFCDQ39545955-9637F7C2-4A18-4212-8D31-3058BC3A3B9AQ39638549-FF76BE40-5E43-48C7-8D58-4A418ABA0C05Q40576938-03719230-37D6-4967-852F-C69C36DD5F21Q40640846-BD9AFB85-C0A4-4BF3-AA90-ACD01D0C89E7Q40763358-92B664EB-968C-40B0-A566-39C50D5A0490Q42511164-007335D3-4AFD-4954-8DA2-ACE39A829E67Q44820325-4FC00015-A0E8-4B49-AE0F-46BB9C5E88D7Q45220730-C4A67F46-B326-4DC5-9E27-E5C98250EEAEQ48273082-08D64EEF-EEC1-4115-922B-6DAC5384DE3DQ49219334-4759A62B-D321-48CF-9C0D-15D4592F9428Q51740449-454776A2-16B5-4746-AACE-10AF223ABCF4Q53284368-0EA8B3EF-0529-454D-95BC-4F502CB6E3CFQ53288015-6D1E8F18-18E2-45FA-B52A-D1D08C11D756Q81747183-A02CDD45-093C-4A3B-B0DC-1C19E06DC6A3
P50
description
Zweeds onderzoekster
@nl
hulumtuese
@sq
researcher
@en
taighdeoir
@ga
հետազոտող
@hy
name
Helena Karlström
@ast
Helena Karlström
@en
Helena Karlström
@es
Helena Karlström
@ga
Helena Karlström
@nl
Helena Karlström
@sl
Helena Karlström
@sq
type
label
Helena Karlström
@ast
Helena Karlström
@en
Helena Karlström
@es
Helena Karlström
@ga
Helena Karlström
@nl
Helena Karlström
@sl
Helena Karlström
@sq
prefLabel
Helena Karlström
@ast
Helena Karlström
@en
Helena Karlström
@es
Helena Karlström
@ga
Helena Karlström
@nl
Helena Karlström
@sl
Helena Karlström
@sq
P106
P1153
6603174279
P21
P27
P31
P496
0000-0002-0498-2473
P569
2000-01-01T00:00:00Z