An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gating
about
An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severityBoth transmembrane domains of BK β1 subunits are essential to confer the normal phenotype of β1-containing BK channelsDistinct domains of the β1-subunit cytosolic N terminus control surface expression and functional properties of large-conductance calcium-activated potassium (BK) channelsBK channel activation: structural and functional insightsKnockout of the BK β2 subunit reveals the importance of accessorizing your channel.Modulation of BK channel gating by the ß2 subunit involves both membrane-spanning and cytoplasmic domains of Slo1.Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels.Regulation of Voltage-Activated K(+) Channel Gating by Transmembrane β Subunits.A role for the S0 transmembrane segment in voltage-dependent gating of BK channels.Regulation of STREX exon large conductance, calcium-activated potassium channels by the beta4 accessory subunit.Modulation of the conductance-voltage relationship of the BK Ca channel by mutations at the putative flexible interface between two RCK domains.Modulation of BK channel voltage gating by different auxiliary β subunits.Subunit-specific effect of the voltage sensor domain on Ca2+ sensitivity of BK channels.The single transmembrane segment determines the modulatory function of the BK channel auxiliary γ subunit.Direct regulation of BK channels by phosphatidylinositol 4,5-bisphosphate as a novel signaling pathwayLocations of the beta1 transmembrane helices in the BK potassium channelModulation of BK Channel Function by Auxiliary Beta and Gamma Subunits.The interface between membrane-spanning and cytosolic domains in Ca²+-dependent K+ channels is involved in β subunit modulation of gating.The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort.Measuring the influence of the BKCa {beta}1 subunit on Ca2+ binding to the BKCa channel.Mechanism of increased BK channel activation from a channel mutation that causes epilepsy.Molecular mechanisms of BK channel activation.Intersubunit coupling in the pore of BK channels.Current understanding of iberiotoxin-resistant BK channels in the nervous system.Shaping of action potentials by type I and type II large-conductance Ca²+-activated K+ channels.Molecular Determinants of BK Channel Functional Diversity and Functioning.An extracellular domain of the accessory β1 subunit is required for modulating BK channel voltage sensor and gate.Integrative Approach for Computationally Inferring Interactions between the Alpha and Beta Subunits of the Calcium-Activated Potassium Channel (BK): a Docking StudyHydrophobic interaction between contiguous residues in the S6 transmembrane segment acts as a stimuli integration node in the BK channel.Lipids modulate the increase of BK channel calcium sensitivity by the β1 subunit{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia.
P2860
Q24645999-83F3ECA3-E0C7-41C9-9BAF-D51DFDE7481BQ28249053-AFB8F751-F992-49A7-84CD-0EA69F5B836FQ33737705-1BD824EB-88CA-49BF-9FFC-08ECC096E89AQ34088616-FA9CD50A-FB2B-48E1-AC9E-EB846533CA31Q34409599-004C49D5-846B-4DA0-AADF-B6F82C1B28BDQ34777392-AE766D9D-58B1-4945-8FB2-AB333880ACECQ35484671-2017158D-405D-4761-9F0B-1878F71BBE83Q35893721-5FBB2B2D-31DC-4819-8CDD-71E3801D8563Q36295991-B3643301-DB11-442E-B612-4FF2C3ED31A1Q36298212-31CE108A-91C9-4AE6-8A5A-4FDC501CB0A2Q36303199-49719546-4A0A-408D-9174-F58EF2CCB591Q36414919-55EABD23-99ED-453B-9EAB-C80F4EE9E888Q36678098-7197DDA1-4CDF-454D-9F28-7CA7F0617A46Q36735302-0411832E-1193-4765-94DF-7C64A57EA395Q36741209-28211F93-0BEF-4C20-B87E-8E6AB3FD4805Q36825326-79E71E73-57A0-435E-971B-BA9DCFF65F67Q37032053-081A62D5-7156-4A02-960A-264721F76833Q37032496-A1430C87-E9DE-4FF6-A1E5-5811FA1C4396Q37088227-F91831D4-5D9E-4951-95EB-87FBFEF18D38Q37089281-2078205E-9FF8-4D7F-B0AF-E88336009B2BQ37124257-CDB22406-524C-4E36-9F06-96AC2B376C41Q37223668-134D78F9-DE16-40AF-9EB9-D93D6AEFF6DCQ37358094-58EB7EC5-9D38-41AB-BFDD-DBF72F4840FAQ38262896-430D1A0D-10B7-489A-8EF1-EE9A0AF9AEDDQ38294483-815B6B8B-F019-42C9-8D9D-5CC66D1FF5E5Q38997044-B0AC1022-B76B-4753-87BA-840445775817Q40118449-3157A649-7B91-40F6-A79B-3D2DE232FAE2Q41595406-54CE1A7C-AF26-4D96-A330-47702EAFD506Q41640525-A76CD250-BE73-4C61-849F-B4FD335A8879Q41840476-CF8BD05C-B32C-4211-AE43-38408B7D0990Q48726839-F0B33E96-B87E-458D-ADB9-67BFC256F445
P2860
An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gating
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
An S6 mutation in BK channels ...... c and voltage-dependent gating
@ast
An S6 mutation in BK channels ...... c and voltage-dependent gating
@en
type
label
An S6 mutation in BK channels ...... c and voltage-dependent gating
@ast
An S6 mutation in BK channels ...... c and voltage-dependent gating
@en
prefLabel
An S6 mutation in BK channels ...... c and voltage-dependent gating
@ast
An S6 mutation in BK channels ...... c and voltage-dependent gating
@en
P2860
P356
P1476
An S6 mutation in BK channels ...... c and voltage-dependent gating
@en
P2093
P2860
P304
P356
10.1085/JGP.200609596
P577
2006-12-01T00:00:00Z