Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.
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Structural Basis for the cAMP-dependent Gating in the Human HCN4 ChannelHyperpolarization-activated graded persistent activity in the prefrontal cortex.Distinct perinatal features of the hyperpolarization-activated non-selective cation current I(h) in the rat cortical plate.Time constants of h current in layer ii stellate cells differ along the dorsal to ventral axis of medial entorhinal cortex.Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels.Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.Functional Characterization of Cnidarian HCN Channels Points to an Early Evolution of Ih.Kinetic relationship between the voltage sensor and the activation gate in spHCN channelsConformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides.Perspectives on: conformational coupling in ion channels: thermodynamics of electromechanical coupling in voltage-gated ion channels.Free-energy relationships in ion channels activated by voltage and ligand.Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortexGating consequences of charge neutralization of arginine residues in the S4 segment of K(v)7.2, an epilepsy-linked K+ channel subunitState-dependent accessibility of the P-S6 linker of pacemaker (HCN) channels supports a dynamic pore-to-gate coupling model.Structure and dynamics underlying elementary ligand binding events in human pacemaking channelsModeling ion channels: past, present, and futureHCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition.Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.Energetics of cyclic AMP binding to HCN channel C terminus reveal negative cooperativity.Ion binding in the open HCN pacemaker channel pore: fast mechanisms to shape "slow" channels.State-dependent cAMP binding to functioning HCN channels studied by patch-clamp fluorometry.Alanine scanning of the S6 segment reveals a unique and cAMP-sensitive association between the pore and voltage-dependent opening in HCN channels.Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core.Activation gating in HCN2 channels.A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
P2860
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P2860
Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.
description
2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
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name
Voltage sensor movement and cA ...... en transition in HCN channels.
@ast
Voltage sensor movement and cA ...... en transition in HCN channels.
@en
type
label
Voltage sensor movement and cA ...... en transition in HCN channels.
@ast
Voltage sensor movement and cA ...... en transition in HCN channels.
@en
prefLabel
Voltage sensor movement and cA ...... en transition in HCN channels.
@ast
Voltage sensor movement and cA ...... en transition in HCN channels.
@en
P2093
P2860
P356
P1476
Voltage sensor movement and cA ...... en transition in HCN channels.
@en
P2093
Meena S George
Steven A Siegelbaum
P2860
P304
P356
10.1085/JGP.200609585
P577
2007-02-01T00:00:00Z