Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering
about
GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytesRegulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifsDensin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transportExocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor)Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transportSynaptic SAP97 isoforms regulate AMPA receptor dynamics and access to presynaptic glutamatePalmitoylation of huntingtin by HIP14 is essential for its trafficking and functionLateral organization of the postsynaptic density2-Bromopalmitate reduces protein deacylation by inhibition of acyl-protein thioesterase enzymatic activitiesProteins that promote filopodia stability, but not number, lead to more axonal-dendritic contactsLigand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channelMolecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complexQuantifying the effects of elastic collisions and non-covalent binding on glutamate receptor trafficking in the post-synaptic densityPSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complexDysregulated striatal neuronal processing and impaired motor behavior in mice lacking huntingtin interacting protein 14 (HIP14)Eye opening induces a rapid dendritic localization of PSD-95 in central visual neuronsSynaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylationPalmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine developmentSubunit-specific regulation of N-methyl-D-aspartate (NMDA) receptor trafficking by SAP102 protein splice variantsSAP102 is a highly mobile MAGUK in spines.Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking.Synaptic targeting and localization of discs-large is a stepwise process controlled by different domains of the proteinLocal palmitoylation cycles define activity-regulated postsynaptic subdomainsNeuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity.Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulationThe fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95.Organization of NMDA receptors at extrasynaptic locations.Association of prenylated proteins with the plasma membrane and the inner nuclear membrane is mediated by the same membrane-targeting motifsTransition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation.PDZ protein interactions regulating glutamate receptor function and plasticityTrafficking of the NMDAR2B receptor subunit distal cytoplasmic tail from endoplasmic reticulum to the synapse.Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice.Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomesAcute inactivation of PSD-95 destabilizes AMPA receptors at hippocampal synapses.ER to synapse trafficking of NMDA receptorsPalmitoylation-dependent protein sorting.
P2860
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P2860
Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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name
Dual palmitoylation of PSD-95 ...... ng, and ion channel clustering
@ast
Dual palmitoylation of PSD-95 ...... ng, and ion channel clustering
@en
type
label
Dual palmitoylation of PSD-95 ...... ng, and ion channel clustering
@ast
Dual palmitoylation of PSD-95 ...... ng, and ion channel clustering
@en
prefLabel
Dual palmitoylation of PSD-95 ...... ng, and ion channel clustering
@ast
Dual palmitoylation of PSD-95 ...... ng, and ion channel clustering
@en
P2093
P2860
P356
P1476
Dual palmitoylation of PSD-95 ...... ng, and ion channel clustering
@en
P2093
A E El-Husseini
B L Firestein
D M Chetkovich
S E Craven
P2860
P304
P356
10.1083/JCB.148.1.159
P407
P577
2000-01-01T00:00:00Z