The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95. - Wikidata - awgldk - TriplyDB

The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95.

The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95.

http://www.wikidata.org/entity/Q33717210

about

Human MicroRNA targets Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function Emerging pharmacotherapies for neurodevelopmental disorders Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure The role of neuronal complexes in human X-linked brain diseases New players tip the scales in the balance between excitatory and inhibitory synapses.Dendritic mRNAs encode diversified functionalities in hippocampal pyramidal neurons Fragile X spectrum disorders The pathophysiology of fragile X (and what it teaches us about synapses)Fragile X-like behaviors and abnormal cortical dendritic spines in cytoplasmic FMR1-interacting protein 2-mutant mice.Downregulation of tonic GABAergic inhibition in a mouse model of fragile X syndrome.Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes.A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability A novel function for fragile X mental retardation protein in translational activation The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model.RNA and microRNAs in fragile X mental retardation Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model.From FMRP function to potential therapies for fragile X syndrome.Fragile X mental retardation protein controls trailer hitch expression and cleavage furrow formation in Drosophila embryos BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability.G-quadruplex RNA structure as a signal for neurite mRNA targeting.Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease.Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity.FMRP mediates mGluR5-dependent translation of amyloid precursor protein.Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5' leader.Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies.The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain.Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome.Dysregulated nitric oxide signaling as a candidate mechanism of fragile X syndrome and other neuropsychiatric disorders.hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies Altered mRNA transport, docking, and protein translation in neurons lacking fragile X mental retardation protein Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis.A feed-forward mechanism involving Drosophila fragile X mental retardation protein triggers a replication stress-induced DNA damage response Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons

P2860

Q21563637-30D04752-5EB6-4F2E-9D3E-CCDA62100118 Q24608468-C599B279-0A61-45F7-8F2F-64EF42A3627F Q24619170-CA5A5BB0-7E88-434D-A123-BE705A3675D5 Q24620534-D73FF616-FEF1-4976-8441-C585DFCFCBB5 Q24645505-25A5385B-1866-4288-A51F-A2B0023C4A5E Q24680472-560C56AA-6810-4AFF-9789-80C6D71457F4 Q24796169-C38A3029-9043-4C12-97EB-22A4722D7FFA Q25256777-BF5BA200-8C36-4D20-B9DD-4FF548C64689 Q26824376-92F90895-E69C-43F8-888A-D8AEEA310CEE Q27010675-A086E0C9-3723-479F-9955-253F1D493E96 Q27301086-A85F5026-A0CE-4D79-B2DF-05E3E4345162 Q27303466-6101403A-F76C-4049-9FB7-45842637C348 Q28114892-3A64B511-6F27-4328-A989-0868A713959B Q28116039-2C8DF84D-B49B-405E-B602-47EC87067259 Q28118268-B7C29526-91A8-43E6-BA0C-6C7EE7A08470 Q28118840-3CD8E385-49DE-4827-AC94-E2FB980E775D Q28261563-2EEB9DCB-B90B-426B-BB68-CEFD461A5553 Q28290772-D4EDAC6C-A5DC-4307-8BA6-78D1D3E934F7 Q28585288-E475F82D-74BC-459E-A85B-4B301780385D Q28771493-073347B3-9C6C-4107-B65E-AFF11120463B Q30362378-FB09917A-9724-42F9-AEBA-EA11EC5DC6A1 Q30410502-357086DA-D6D4-4FCD-8099-70C555734571 Q30479193-59CF4B31-958C-4983-8B19-74DD99866B94 Q30494390-568916C0-2E76-47D0-8D45-48BC553C9DFC Q30502060-8D4371C3-6D54-4840-A053-B26D06B64E98 Q30580280-85E2464A-45DB-42C2-A171-2CB4CA6303E6 Q30838839-9BFC218E-F874-4B55-8104-5A4B01D0CB04 Q33212164-64DCA741-6AF8-4DBA-B94C-20274ADE9A5A Q33273636-E99C7C51-4AE3-4A85-B173-54CCDABF5C6A Q33376873-5FF6E6F6-55B4-4B01-815A-BA635CC141DD Q33775386-A83F2120-5215-45A3-AF7C-C8422FCEB504 Q33838422-3E3F6860-5CA9-4C0B-A5F7-5D326ADC3584 Q33914148-4584859D-D11F-46D7-99F5-A44C6225ECAA Q33929361-1C4F13F2-550C-4D1D-B3EA-3E4739BA09EF Q34013644-1E383FB3-E7B1-4907-BC5D-29E0713A5924 Q34100256-837AA4F6-2220-416B-AAE4-27D1D492D034 Q34108310-79FF1B7F-550F-49EE-B1E7-E730FAAEC454 Q34155406-F4738A75-D671-41E5-9AB0-EA04EE17C9B5 Q34200046-2903F14E-55A7-4665-9E5A-61CBC8EE6820 Q34316545-627FB1E0-7445-4A1E-A9CA-8FEA1402D8A4

P2860

The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95.

http://www.wikidata.org/entity/Q33717210

description

2003 nî lūn-bûn

@nan

2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

The fragile X mental retardati ...... pendent translation of PSD-95.

@ast

The fragile X mental retardati ...... pendent translation of PSD-95.

@en

type

label

The fragile X mental retardati ...... pendent translation of PSD-95.

@ast

The fragile X mental retardati ...... pendent translation of PSD-95.

@en

prefLabel

The fragile X mental retardati ...... pendent translation of PSD-95.

@ast

The fragile X mental retardati ...... pendent translation of PSD-95.

@en

P1433

Q33717210-C9B9DA6F-3134-43EC-905D-350E57E53922

P1476

Q33717210-AEDE67B6-107A-44E9-B1C3-C28BA870C567

P2093

Q33717210-5F19E04F-641F-4380-A512-6DA7026AB926

Q33717210-D1C9A251-2E81-4026-B3B9-263F75818B47

Q33717210-F261FE8E-38BF-477C-9BAF-A0F80E425C55

P2860

Q33717210-0D0CE728-5C1C-4D41-AF1C-E4BAA9A2CED6

Q33717210-0F4C00D1-1F63-4068-ABC0-C435374C2789

Q33717210-123B99F5-8A6B-4BFA-BB7C-66958E0762E9

Q33717210-1F805555-6A8D-4C12-A5CE-1F486AA76E43

Q33717210-230485EE-C2A3-4B38-B1E6-C8733EC15613

Q33717210-278F2D6D-DB2F-4465-BE1D-3C18F44288D6

Q33717210-281F02AA-03E7-44E3-9C8D-93345314A18F

Q33717210-282C80A3-579D-45B2-83BC-7E7FDA0BC530

Q33717210-2A91987B-8E36-43FF-96CE-D2F749BA94E1

Q33717210-307DD036-D71F-45A2-AB5E-4BD5604598E2

P304

Q33717210-CD1BC5C9-1AE1-4325-951E-7401C6A7FE5A

P31

Q33717210-220A6155-DE60-4A59-8CD3-F55C1522C60E

P356

Q33717210-9D3A8A29-8887-4E79-B3F9-359590C4F2FD

P407

Q33717210-1DA7C6B0-59A5-4BB5-89CC-DF4F10357D4C

P433

Q33717210-8E07B4FE-C629-487F-A117-FA1B9E8366C9

P478

Q33717210-7AF42128-E92D-42C3-BF9C-97386FE2FC2F

P577

Q33717210-D84B4CA6-1F26-4CA5-A01B-EB35CC1EE68E

P5875

Q33717210-BCD9E3B1-74CD-4AE0-8E15-F6BD7BE64682

P698

Q33717210-6D9D72C6-3A1B-472D-866E-F129B5ABF3D4

P932

Q33717210-659AD72B-0654-496D-BBCA-BCC1417A3BA2

P356

PNAS.2336265100

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

The fragile X mental retardati ...... pendent translation of PSD-95.

@en

P2093

James S Malter

http://www.w3.org/2001/XMLSchema#string

Kenneth J Mack

http://www.w3.org/2001/XMLSchema#string

Peter K Todd

http://www.w3.org/2001/XMLSchema#string

P2860

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex

Metabotropic glutamate receptors trigger postsynaptic protein synthesis

Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits

Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association

Evidence that fragile X mental retardation protein is a negative regulator of translation

Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein

Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes

P304

14374-14378

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.2336265100

http://www.w3.org/2001/XMLSchema#string

P407

P433

24

http://www.w3.org/2001/XMLSchema#string

P478

100

http://www.w3.org/2001/XMLSchema#string

P577

2003-11-12T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

9012223

http://www.w3.org/2001/XMLSchema#string

P698

14614133

http://www.w3.org/2001/XMLSchema#string

P932

283599

http://www.w3.org/2001/XMLSchema#string