Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice.
about
Human SM22 alpha BAC encompasses regulatory sequences for expression in vascular and visceral smooth muscles at fetal and adult stagesCalcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycleSNPs3D: candidate gene and SNP selection for association studies.Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidasesMast cell peptidases: chameleons of innate immunity and host defense.Advanced glycation end products activate a chymase-dependent angiotensin II-generating pathway in diabetic complications.Mast cell proteases as pharmacological targetsIn vivo expression of a conditional TGF-beta1 transgene: no evidence for TGF-beta1 transgene expression in SM22alpha-tTA transgenic miceTissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut.Mast cell tryptases and chymases in inflammation and host defense.Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden deathInvolvement of chymase-mediated angiotensin II generation in blood pressure regulation.Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response.Effects of chymostatin, a chymase inhibitor, on blood pressure, plasma and tissue angiotensin II, renal haemodynamics and renal excretion in two models of hypertension in the rat.MFG-E8 activates proliferation of vascular smooth muscle cells via integrin signaling.Enhanced vascular chymase-dependent conversion of endothelin in the diabetic kidney.Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veinsThe functional role of the renin-angiotensin system in pregnancy and preeclampsia.Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling.Alpha 2-macroglobulin capture allows detection of mast cell chymase in serum and creates a reservoir of angiotensin II-generating activity.Mast cell proteases as protective and inflammatory mediators.Long-term blood pressure control: is there a set-point in the brain?Big ET-1 processing into vasoactive peptides in arteries and veins.Conditional overexpression of transgenes in megakaryocytes and platelets in vivo.Cardiac interstitial bradykinin and mast cells modulate pattern of LV remodeling in volume overload in rats.Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression.Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling.
P2860
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P2860
Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice.
description
2001 nî lūn-bûn
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2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
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2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
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2001年學術文章
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2001年學術文章
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name
Conditional and targeted overe ...... pertension in transgenic mice.
@ast
Conditional and targeted overe ...... pertension in transgenic mice.
@en
type
label
Conditional and targeted overe ...... pertension in transgenic mice.
@ast
Conditional and targeted overe ...... pertension in transgenic mice.
@en
prefLabel
Conditional and targeted overe ...... pertension in transgenic mice.
@ast
Conditional and targeted overe ...... pertension in transgenic mice.
@en
P2093
P2860
P356
P1476
Conditional and targeted overe ...... pertension in transgenic mice.
@en
P2093
P2860
P304
P356
10.1073/PNAS.131147598
P407
P577
2001-06-01T00:00:00Z