Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes
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A critical role for the transcription factor Scl in platelet production during stress thrombopoiesisA secreted tyrosine kinase acts in the extracellular environmentMutations in human nonmuscle myosin IIA found in patients with May-Hegglin anomaly and Fechtner syndrome result in impaired enzymatic functionACTN1 mutations cause congenital macrothrombocytopeniaMegakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.Platelet generation in vivo and in vitroRole of autophagy in megakaryocyte differentiation and platelet formationMegakaryocyte- and megakaryocyte precursor-related gene therapiesStem cell autotomy and niche interaction in different systemsStem cells, megakaryocytes, and plateletsTranscription factors in late megakaryopoiesis and related platelet disordersPluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical applicationIL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in ThrombopoiesisCharacterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis.Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) miceRab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesisMutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopeniaRanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubulesSerum response factor is an essential transcription factor in megakaryocytic maturationSynergistic effect of hydrogen peroxide on polyploidization during the megakaryocytic differentiation of K562 leukemia cells by PMA.Properties of the demarcation membrane system in living rat megakaryocytes.A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentationThe megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesisExpression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2.Mechanisms of organelle transport and capture along proplatelets during platelet production.Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes.Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules.Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticlesIntrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells.Infusion of mature megakaryocytes into mice yields functional platelets.Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes.The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis.T granules in human platelets function in TLR9 organization and signaling.LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B.Outside-in signalling generated by a constitutively activated integrin αIIbβ3 impairs proplatelet formation in human megakaryocytes.Lonely in Paris: when one gene copy isn't enough.The biogenesis of platelets from megakaryocyte proplatelets.
P2860
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P2860
Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Blood platelets are assembled ...... differentiated megakaryocytes
@ast
Blood platelets are assembled ...... differentiated megakaryocytes
@en
type
label
Blood platelets are assembled ...... differentiated megakaryocytes
@ast
Blood platelets are assembled ...... differentiated megakaryocytes
@en
prefLabel
Blood platelets are assembled ...... differentiated megakaryocytes
@ast
Blood platelets are assembled ...... differentiated megakaryocytes
@en
P2093
P2860
P356
P1476
Blood platelets are assembled ...... differentiated megakaryocytes
@en
P2093
J E Italiano
J H Hartwig
R A Shivdasani
P2860
P304
P356
10.1083/JCB.147.6.1299
P407
P577
1999-12-01T00:00:00Z