Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes - Wikidata - awgldk - TriplyDB

Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes

Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes

http://www.wikidata.org/entity/Q36313419

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A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis A secreted tyrosine kinase acts in the extracellular environment Mutations in human nonmuscle myosin IIA found in patients with May-Hegglin anomaly and Fechtner syndrome result in impaired enzymatic function ACTN1 mutations cause congenital macrothrombocytopenia Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.Platelet generation in vivo and in vitro Role of autophagy in megakaryocyte differentiation and platelet formation Megakaryocyte- and megakaryocyte precursor-related gene therapies Stem cell autotomy and niche interaction in different systems Stem cells, megakaryocytes, and platelets Transcription factors in late megakaryopoiesis and related platelet disorders Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis.Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules Serum response factor is an essential transcription factor in megakaryocytic maturation Synergistic effect of hydrogen peroxide on polyploidization during the megakaryocytic differentiation of K562 leukemia cells by PMA.Properties of the demarcation membrane system in living rat megakaryocytes.A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2.Mechanisms of organelle transport and capture along proplatelets during platelet production.Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes.Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules.Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells.Infusion of mature megakaryocytes into mice yields functional platelets.Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes.The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis.T granules in human platelets function in TLR9 organization and signaling.LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B.Outside-in signalling generated by a constitutively activated integrin αIIbβ3 impairs proplatelet formation in human megakaryocytes.Lonely in Paris: when one gene copy isn't enough.The biogenesis of platelets from megakaryocyte proplatelets.

P2860

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P2860

Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes

http://www.wikidata.org/entity/Q36313419

description

1999 nî lūn-bûn

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1999年の論文

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年學術文章

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1999年學術文章

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1999年學術文章

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name

Blood platelets are assembled ...... differentiated megakaryocytes

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Blood platelets are assembled ...... differentiated megakaryocytes

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label

Blood platelets are assembled ...... differentiated megakaryocytes

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Blood platelets are assembled ...... differentiated megakaryocytes

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prefLabel

Blood platelets are assembled ...... differentiated megakaryocytes

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Blood platelets are assembled ...... differentiated megakaryocytes

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Journal of Cell Biology

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Blood platelets are assembled ...... differentiated megakaryocytes

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P2093

J E Italiano

http://www.w3.org/2001/XMLSchema#string

J H Hartwig

http://www.w3.org/2001/XMLSchema#string

R A Shivdasani

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P2860

Megakaryocyte morphogenesis stimulated in vitro by whole and partially fractionated thrombocytopenic plasma: a model system for the study of platelet formation.

Thrombokinetics in man.

Thrombopoietin: the primary regulator of platelet production.

Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes.

Reorganization of actin in platelets stimulated by thrombin as measured by the DNase I inhibition assay.

Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional.

Mechanisms of platelet production.

Microtubules in hamster platelets

Actin filament content and organization in unstimulated platelets

An electron microscope study of the megacaryocyte of the rat bone marrow. I. The development of the demarcation membrane system and the platelet surface coat.

P304

1299-1312

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scholarly article

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10.1083/JCB.147.6.1299

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6

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147

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Patrick Lécine

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1999-12-01T00:00:00Z

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277549205

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10601342

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2168104

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