Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents. - Wikidata - awgldk - TriplyDB

Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

http://www.wikidata.org/entity/Q36320180

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Biotin Protein Ligase Is a Target for New Antibacterials Recent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetases Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification tRNAs as antibiotic targets In silico discovery of aminoacyl-tRNA synthetase inhibitors Asparagine requirement in Plasmodium berghei as a target to prevent malaria transmission and liver infections.Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica Crystal Structures of Trypanosomal Histidyl-tRNA Synthetase Illuminate Differences between Eukaryotic and Prokaryotic Homologs Flexibility and communication within the structure of the Mycobacterium smegmatis methionyl-tRNA synthetase The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer Structural Basis for Microcin C7 Inactivation by the MccE Acetyltransferase Structure of the prolyl-tRNA synthetase from the eukaryotic pathogenGiardia lamblia Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis Selective inhibition of Biotin Protein Ligase from Staphylococcus aureus Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase Structural analysis of malaria-parasite lysyl-tRNA synthetase provides a platform for drug development Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo Comparative genomics analysis of Mycobacterium ulcerans for the identification of putative essential genes and therapeutic candidates Novel hybrid virtual screening protocol based on molecular docking and structure-based pharmacophore for discovery of methionyl-tRNA synthetase inhibitors as antibacterial agents Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin Unusual domain architecture of aminoacyl tRNA synthetases and their paralogs from Leishmania major Genome-wide Analysis of Mycoplasma hominis for the Identification of Putative Therapeutic Targets.High-resolution transcriptomic analysis of the adaptive response of Staphylococcus aureus during acute and chronic phases of osteomyelitis.Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors.Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.Novel and unique domains in aminoacyl-tRNA synthetases from human fungal pathogens Aspergillus niger, Candida albicans and Cryptococcus neoformans.Encyclopedia of bacterial gene circuits whose presence or absence correlate with pathogenicity--a large-scale system analysis of decoded bacterial genomes Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.A human leucyl-tRNA synthetase as an anticancer target Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii.Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents.Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin.Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition.Advances in Drug Discovery and Development for Pediatric Tuberculosis.Adenylating enzymes in Mycobacterium tuberculosis as drug targets.

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P2860

Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

http://www.wikidata.org/entity/Q36320180

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2005 nî lūn-bûn

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2005年学术文章

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2005年學術文章

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2005年學術文章

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Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

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Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

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Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

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Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

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Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

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Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

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AAC.49.12.4821-4833.2005

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Antimicrobial Agents and Chemotherapy

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Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

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Alexander John O'Neill

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Ian Chopra

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Julian Gregston Hurdle

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P2860

Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Escherichia coli by pseudomonic acid

High-level mupirocin resistance in Staphylococcus aureus: evidence for two distinct isoleucyl-tRNA synthetases

Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase

Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations

A new view of the mechanisms of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate-3-phosphate synthase (AroA) derived from X-ray structures of their tetrahedral reaction intermediate states

Interaction of indolmycin in the metabolism of tryptophan in rat liver

Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs

Aminoacyl-tRNA synthesis

Relationship of protein structure of isoleucyl-tRNA synthetase with pseudomonic acid resistance of Escherichia coli. A proposed mode of action of pseudomonic acid as an inhibitor of isoleucyl-tRNA synthetase.

Drug target validation: lethal infection blocked by inducible peptide.

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4821-4833

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10.1128/AAC.49.12.4821-4833.2005

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