Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway. - Wikidata - awgldk - TriplyDB

Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway.

Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway.

http://www.wikidata.org/entity/Q36321788

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Oligodendrogenesis in the normal and pathological central nervous system Amyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET Imaging Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation Mitochondrial lipids in neurodegeneration Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse Diffusion tensor MRI as a biomarker in axonal and myelin damage.Alzheimer's disease and the fornix.Identification of Mg2+ -dependent neutral sphingomyelinase 1 as a mediator of heat stress-induced ceramide generation and apoptosis.Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosis Cross-talk of membrane lipids and Alzheimer-related proteins.Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease.Deregulation of sphingolipid metabolism in Alzheimer's disease.Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease.Alterations in working memory as a function of leukoaraiosis in dementia Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target.Soluble amyloid beta levels are elevated in the white matter of Alzheimer's patients, independent of cortical plaque severity.Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease.Amyloid β1-42 oligomer inhibits myelin sheet formation in vitro.Physicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimer's disease.Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer's disease.The pathological roles of ganglioside metabolism in Alzheimer's disease: effects of gangliosides on neurogenesis.Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells.Regulation of phosphatidic Acid metabolism by sphingolipids in the central nervous system Bioactive sphingolipids: metabolism and function Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling.Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease.Src regulates cigarette smoke-induced ceramide generation via neutral sphingomyelinase 2 in the airway epithelium Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease.Neutral sphingomyelinase-2 is a redox sensitive enzyme: role of catalytic cysteine residues in regulation of enzymatic activity through changes in oligomeric state.Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease Collapsin response mediator protein-2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non-lethal oxidative stress.The 5XFAD Mouse Model of Alzheimer's Disease Exhibits an Age-Dependent Increase in Anti-Ceramide IgG and Exogenous Administration of Ceramide Further Increases Anti-Ceramide Titers and Amyloid Plaque Burden.Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II.Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia.Phospholipids and Alzheimer's disease: alterations, mechanisms and potential biomarkers.

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Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway.

http://www.wikidata.org/entity/Q36321788

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Amyloid-beta peptide induces o ...... ngomyelinase-ceramide pathway.

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Amyloid-beta peptide induces o ...... ngomyelinase-ceramide pathway.

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Amyloid-beta peptide induces o ...... ngomyelinase-ceramide pathway.

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P2093

Ding-I Yang

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Grace Ku

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Jiunn-Tay Lee

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Shawei Chen

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Xianlin Han

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P2860

Protein measurement with the Folin phenol reagent

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1

Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals

Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches.

Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle

Signalling sphingomyelinases: which, where, how and why?

The role of oxidative stress in Alzheimer disease.

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