Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease
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Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's diseaseCeramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ AccumulationNeutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localizationA novel mitochondrial sphingomyelinase in zebrafish cells.Increase in sphingolipid catabolic enzyme activity during aging.Cross-talk of membrane lipids and Alzheimer-related proteins.Deregulation of sphingolipid metabolism in Alzheimer's disease.NOX activity is increased in mild cognitive impairmentPlasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume lossAlzheimer's proteins, oxidative stress, and mitochondrial dysfunction interplay in a neuronal model of Alzheimer's disease.Ceramide and Related-Sphingolipid Levels Are Not Altered in Disease-Associated Brain Regions of APP and APP/PS1 Mouse Models of Alzheimer's Disease: Relationship with the Lack of Neurodegeneration?Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer's disease.Formation of Toxic Amyloid Fibrils by Amyloid β-Protein on Ganglioside Clusters.Regulation of phosphatidic Acid metabolism by sphingolipids in the central nervous systemStress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling.Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?Lipid raft redox signaling: molecular mechanisms in health and disease.Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease.Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer's DiseaseNADPH oxidase inhibition improves neurological outcomes in surgically-induced brain injury.HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.Redox regulation of cytokine-mediated inhibition of myelin gene expression in human primary oligodendrocytes.Gemfibrozil, a lipid lowering drug, inhibits the activation of primary human microglia via peroxisome proliferator-activated receptor β.The 1027th target candidate in stroke: Will NADPH oxidase hold up?Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II.A simplified method for isolating highly purified neurons, oligodendrocytes, astrocytes, and microglia from the same human fetal brain tissue.Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.Oxidative stress kills human primary oligodendrocytes via neutral sphingomyelinase: implications for multiple sclerosis.Gemfibrozil, a lipid-lowering drug, upregulates IL-1 receptor antagonist in mouse cortical neurons: implications for neuronal self-defenseNeuronal human BACE1 knockin induces systemic diabetes in mice.Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death.Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor α.NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea.TNF-alpha preconditioning protects neurons via neuron-specific up-regulation of CREB-binding protein.NADPH oxidase drives cytokine and neurotoxin release from microglia and macrophages in response to HIV-Tat.Mild systemic oxidative stress in the subclinical stage of Alzheimer's disease.Serum sphingomyelins and ceramides are early predictors of memory impairmentA biological perspective of CSF lipids as surrogate markers for cognitive status in HIVNADPH oxidase in brain injury and neurodegenerative disordersAPP Function and Lipids: A Bidirectional Link.
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P2860
Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Fibrillar amyloid-beta peptide ...... ations for Alzheimer's disease
@ast
Fibrillar amyloid-beta peptide ...... ations for Alzheimer's disease
@en
type
label
Fibrillar amyloid-beta peptide ...... ations for Alzheimer's disease
@ast
Fibrillar amyloid-beta peptide ...... ations for Alzheimer's disease
@en
prefLabel
Fibrillar amyloid-beta peptide ...... ations for Alzheimer's disease
@ast
Fibrillar amyloid-beta peptide ...... ations for Alzheimer's disease
@en
P2860
P356
P1476
Fibrillar amyloid-beta peptide ...... ations for Alzheimer's disease
@en
P2093
Arundhati Jana
Kalipada Pahan
P2860
P304
51451-51459
P356
10.1074/JBC.M404635200
P407
P577
2004-09-27T00:00:00Z