Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368.
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Levonorgestrel Inhibits Human Endometrial Cell Proliferation through the Upregulation of Gap Junctional Intercellular Communication via the Nuclear Translocation of Ser255 Phosphorylated Cx43Posttranslational modifications in connexins and pannexinsTargeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPasesThe Role of Connexins in Wound Healing and Repair: Novel Therapeutic ApproachesSelectivity of connexin 43 channels is regulated through protein kinase C-dependent phosphorylation.Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation.Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair.Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injuryConnexin43 interacts with βarrestin: a pre-requisite for osteoblast survival induced by parathyroid hormoneTargeting connexin 43 with α-connexin carboxyl-terminal (ACT1) peptide enhances the activity of the targeted inhibitors, tamoxifen and lapatinib, in breast cancer: clinical implication for ACT1Expression and function of connexin 43 in human gingival wound healing and fibroblastsTemporal regulation of connexin phosphorylation in embryonic and adult tissues.Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues.Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stabilityCASK (LIN2) interacts with Cx43 in wounded skin and their coexpression affects cell migration.Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotectionPhosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC.ZO-1 is required for protein kinase C gamma-driven disassembly of connexin 43mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice.Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding.Effect of connexin 43 inhibition by the mimetic peptide Gap27 on corneal wound healing, inflammation and neovascularization.Connexin43 phosphorylation: structural changes and biological effects.Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size.Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells.Specific Cx43 phosphorylation events regulate gap junction turnover in vivoGap junction remodeling in skin repair following wounding and disease.Regulation of connexin- and pannexin-based channels by post-translational modifications.Cardiac to cancer: connecting connexins to clinical opportunity.Connexins: sensors of epidermal integrity that are therapeutic targets.Connexin43 plays diverse roles in co-ordinating cell migration and wound closure events.Spatio-temporal regulation of connexin43 phosphorylation and gap junction dynamics.Diabetes Increases Cryoinjury Size with Associated Effects on Cx43 Gap Junction Function and Phosphorylation in the Mouse Heart.Migrating cells retain gap junction plaque structure and function.Herpes simplex virus-type 2 infectivity and agents that block gap junctional intercellular communication.The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants.A Snapshot of Direct Cell-Cell Communications in Wound Healing and Scarring.A Connexin43 Mimetic Peptide Promotes Regenerative Healing and Improves Mechanical Properties in Skin and Heart.Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets.
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P2860
Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Protein kinase C spatially and ...... on of connexin43 on serine368.
@ast
Protein kinase C spatially and ...... on of connexin43 on serine368.
@en
type
label
Protein kinase C spatially and ...... on of connexin43 on serine368.
@ast
Protein kinase C spatially and ...... on of connexin43 on serine368.
@en
prefLabel
Protein kinase C spatially and ...... on of connexin43 on serine368.
@ast
Protein kinase C spatially and ...... on of connexin43 on serine368.
@en
P2093
P2860
P356
P1476
Protein kinase C spatially and ...... on of connexin43 on serine368.
@en
P2093
Clarence A Dunn
John E Olerud
Marcia L Usui
Paul D Lampe
Theresa S Richards
William G Carter
P2860
P304
P356
10.1083/JCB.200404142
P407
P577
2004-11-01T00:00:00Z