A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase.
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Mechanisms of CFTR Folding at the Endoplasmic ReticulumDeletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperoneEndoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligaseRNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substratesBAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.Mechanisms for quality control of misfolded transmembrane proteinsProtein homeostasis at the plasma membraneRoles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degenerationSolution Structure of RING Finger-like Domain of Retinoblastoma-binding Protein-6 (RBBP6) Suggests It Functions as a U-boxUbr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins.Regulation of the cytoplasmic quality control protein degradation pathway by BAG2The primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domainThe endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508Augmentation of CFTR maturation by S-nitrosoglutathione reductase.Chaperone functions of the E3 ubiquitin ligase CHIP.ER-associated complexes (ERACs) containing aggregated cystic fibrosis transmembrane conductance regulator (CFTR) are degraded by autophagy.The role of the UPS in cystic fibrosis.The calpain, caspase 12, caspase 3 cascade leading to apoptosis is altered in F508del-CFTR expressing cellsUbe2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates.Enhancing the Potency of F508del Correction: A Multi-Layer Combinational Approach to Drug Discovery for Cystic Fibrosis.Hsp40 chaperones promote degradation of the HERG potassium channel.Complement yourself: Transcomplementation rescues partially folded mutant proteins.Ubiquitin C-terminal hydrolase-L1 protects cystic fibrosis transmembrane conductance regulator from early stages of proteasomal degradation.Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexinHeat shock protein 70 (hsp70) as an emerging drug target.Type I transglutaminase accumulation in the endoplasmic reticulum may be an underlying cause of autosomal recessive congenital ichthyosis.Hsp70- and Hsp90-mediated proteasomal degradation underlies TPI sugarkill pathogenesis in Drosophila.Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis.Human homologs of Ubc6p ubiquitin-conjugating enzyme and phosphorylation of HsUbc6e in response to endoplasmic reticulum stress.Emergent properties of proteostasis in managing cystic fibrosis.FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells.Ubiquitin-proteasome pathway and cellular responses to oxidative stress.Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation.An RNA aptamer specific to Hsp70-ATP conformation inhibits its ATPase activity independent of Hsp40.Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiaeGenetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signalA network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast.Regulation of ubiquitin-proteasome system mediated degradation by cytosolic stress.
P2860
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P2860
A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
A foldable CFTR{Delta}F508 bio ...... sc70-CHIP E3 ubiquitin ligase.
@ast
A foldable CFTR{Delta}F508 bio ...... sc70-CHIP E3 ubiquitin ligase.
@en
type
label
A foldable CFTR{Delta}F508 bio ...... sc70-CHIP E3 ubiquitin ligase.
@ast
A foldable CFTR{Delta}F508 bio ...... sc70-CHIP E3 ubiquitin ligase.
@en
prefLabel
A foldable CFTR{Delta}F508 bio ...... sc70-CHIP E3 ubiquitin ligase.
@ast
A foldable CFTR{Delta}F508 bio ...... sc70-CHIP E3 ubiquitin ligase.
@en
P2093
P2860
P356
P1476
A foldable CFTR{Delta}F508 bio ...... sc70-CHIP E3 ubiquitin ligase.
@en
P2093
Andrea Fields
Cam Patterson
Chun-Yang Fan
Douglas M Cyr
Hong-Yu Ren
J Michael Younger
Liling Chen
P2860
P304
P356
10.1083/JCB.200410065
P407
P577
2004-12-01T00:00:00Z