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Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the diseaseIn vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulationSequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growthMechanisms of neuregulin actionDeficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZFVisualization of Neuregulin 1 ectodomain shedding reveals its local processing in vitro and in vivo.New insights on Schwann cell developmentNeuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathwayLrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapsesThe neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity.Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit componentsIntramembranous valine linked to schizophrenia is required for neuregulin 1 regulation of the morphological development of cortical neuronsPresynaptic type III neuregulin1-ErbB signaling targets {alpha}7 nicotinic acetylcholine receptors to axonsGamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrinDeletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementiaSchizophrenia genes, gene expression, and neuropathology: on the matter of their convergenceInvestigation of gene effects and epistatic interactions between Akt1 and neuregulin 1 in the regulation of behavioral phenotypes and social functions in genetic mouse models of schizophrenia.Expression profiling reveals differential gene induction underlying specific and non-specific memory for pheromones in mice.Age-related neuronal loss in the cochlea is not delayed by synaptic modulation.Disrupted activity in the hippocampal-accumbens circuit of type III neuregulin 1 mutant miceModeling an anti-amyloid combination therapy for Alzheimer's disease.Distinct phenotypes of new transmembrane-domain neuregulin 1 mutant mice and the rescue effects of valproate on the observed schizophrenia-related cognitive deficitsA negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanismsAssociation study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample.ADAM-17: the enzyme that does it all.Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Nuclear trafficking of the epidermal growth factor receptor family membrane proteins.Type III Nrg1 back signaling enhances functional TRPV1 along sensory axons contributing to basal and inflammatory thermal pain sensationCharacterization of glial cell models and in vitro manipulation of the neuregulin1/ErbB systemThe neuregulin signaling pathway and schizophrenia: from genes to synapses and neural circuits.EGFs and ERBBs--brief history and prospectsActivity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos.TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.Disturbed macro-connectivity in schizophrenia linked to oligodendrocyte dysfunction: from structural findings to molecules.Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands.Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development.Type III neuregulin 1 regulates pathfinding of sensory axons in the developing spinal cord and periphery.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Back signaling by the Nrg-1 intracellular domain
@ast
Back signaling by the Nrg-1 intracellular domain
@en
type
label
Back signaling by the Nrg-1 intracellular domain
@ast
Back signaling by the Nrg-1 intracellular domain
@en
prefLabel
Back signaling by the Nrg-1 intracellular domain
@ast
Back signaling by the Nrg-1 intracellular domain
@en
P2860
P50
P356
P1476
Back signaling by the Nrg-1 intracellular domain
@en
P2093
Jianxin Bao
P2860
P304
P356
10.1083/JCB.200212085
P407
P577
2003-06-01T00:00:00Z