Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest
about
Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrestTelomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicaseHomologous Recombination and Its Role in CarcinogenesisThe role of RecQ helicases in non-homologous end-joiningAn N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATMUnwinding protein complexes in ALTernative telomere maintenance.Viral transport of DNA damage that mimics a stalled replication fork.Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8.Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.Aspergillus nidulans uvsBATR and scaANBS1 genes show genetic interactions during recovery from replication stress and DNA damagePhosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaksJunction of RecQ helicase biochemistry and human disease.Time to bloom.Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses.BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombinationTemplate disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants.RecQ helicases: suppressors of tumorigenesis and premature aging.Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrestRECQ1 plays a distinct role in cellular response to oxidative DNA damage.Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phasesBloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks.Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stressContributions of DNA interstrand cross-links to aging of cells and organisms.MRE11 complex links RECQ5 helicase to sites of DNA damage.S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesionRecQ helicases; at the crossroad of genome replication, repair, and recombination.Replication fork dynamics and the DNA damage response.Quality control of homologous recombination.Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability.Chromosome breakage is regulated by the interaction of the BLM helicase and topoisomerase IIalpha.Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates.BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks.The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.Disruption of the BLM gene in ATM-null DT40 cells does not exacerbate either phenotype.Nbs1 is required for ATR-dependent phosphorylation events.Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation.
P2860
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P2860
Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Bloom's syndrome protein is re ...... after replication fork arrest
@ast
Bloom's syndrome protein is re ...... after replication fork arrest
@en
type
label
Bloom's syndrome protein is re ...... after replication fork arrest
@ast
Bloom's syndrome protein is re ...... after replication fork arrest
@en
prefLabel
Bloom's syndrome protein is re ...... after replication fork arrest
@ast
Bloom's syndrome protein is re ...... after replication fork arrest
@en
P2860
P356
P1476
Bloom's syndrome protein is re ...... after replication fork arrest
@en
P2860
P356
10.1083/JCB.200110009
P407
P577
2002-03-26T00:00:00Z