Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner.
about
PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture.Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling.Fibronectin expression modulates mammary epithelial cell proliferation during acinar differentiationTransforming properties of YAP, a candidate oncogene on the chromosome 11q22 ampliconmTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling AxisTherapeutic potential of targeting acinar cell reprogramming in pancreatic cancerIκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathwayUnraveling the microenvironmental influences on the normal mammary gland and breast cancerThe 18-kDa translocator protein (TSPO) disrupts mammary epithelial morphogenesis and promotes breast cancer cell migrationActive PI3K pathway causes an invasive phenotype which can be reversed or promoted by blocking the pathway at divergent nodesIdentifying single-cell molecular programs by stochastic profiling.Starved epithelial cells uptake extracellular matrix for survival.Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells.N-cadherin/FGFR promotes metastasis through epithelial-to-mesenchymal transition and stem/progenitor cell-like properties.A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance.Mammary gene expression profiles during an intramammary challenge reveal potential mechanisms linking negative energy balance with impaired immune responseBim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.A structure-guided approach to creating covalent FGFR inhibitorsModeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformationGene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancerThe need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancerThe role of fibroblast Tiam1 in tumor cell invasion and metastasisDisruption of 3D MCF-12A breast cell cultures by estrogens--an in vitro model for ER-mediated changes indicative of hormonal carcinogenesis.Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations.Reactive oxygen species via redox signaling to PI3K/AKT pathway contribute to the malignant growth of 4-hydroxy estradiol-transformed mammary epithelial cellsUse of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis.Type I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cellsDAPK3 suppresses acini morphogenesis and is required for mouse development.N-cadherin regulates mammary tumor cell migration through Akt3 suppression.The PI 3-kinase and mTOR signaling pathways are important modulators of epithelial tubule formationModeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.ERα-mediated repression of pro-inflammatory cytokine expression by glucocorticoids reveals a crucial role for TNFα and IL1α in lumen formation and maintenanceMammary epithelial cell polarity is regulated differentially by p73 isoforms via epithelial-to-mesenchymal transition.Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations.K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc.Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension.Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model.PH motifs in PAR1&2 endow breast cancer growth.
P2860
Q22000770-B07D2CBF-1309-436A-9B3A-0CDDB2FA0DCAQ24567499-30866DAC-F664-4478-BDFF-B0D7A214CCA1Q24649457-D8EE03DD-39BF-4513-80E8-0D3A1FCE848FQ24682018-4AE60A78-BE4A-4641-902B-AE53BC95FE4EQ27310985-55474311-1073-45C2-9459-D07C06510EB6Q28068998-FFD8FD26-B910-4DC2-A667-7C254F5A6A14Q28116229-B3B4452C-2B28-46DA-ACE0-554E9455E96AQ28473677-750FEC59-91F8-4FD8-BAA1-C96B11DEFE83Q28535344-BDB2729B-2ABC-45BA-9651-0AD9298B0FF4Q28730141-07AB0CB2-CB19-4024-95A9-A9D17954B625Q30434682-132F67E7-254C-4BC4-99BD-288F53239DDCQ30834870-DD46A7D3-B404-474A-822A-D0C12EB05F65Q30852504-C7A21312-15A0-406E-ACA0-C72D258017F8Q33734993-FDB1B0A4-928A-4F8B-B7BA-0777030BC907Q33769618-A012AF09-0068-45B6-9372-4A7E51B165B7Q33816520-3D8828CE-9AD3-49C0-BF86-9C8B0F6CC0E9Q33837060-4EDACC35-844F-47AF-9C6C-19E10234F719Q34061522-08E6DC71-9BE7-41DC-8DD8-D70D66C67E80Q34103419-A7AD8E4A-46E8-4FDE-B753-3F557319DEFCQ34103462-74F4BED1-6988-4E58-A47E-CF1A99816D45Q34291977-7F6DB282-F085-4120-B9E1-4F4ED0F24EEBQ34384857-940920D4-5D4F-4A27-8F61-47F73213B911Q34440985-2A06ED6C-11BF-4404-8644-96DFD2352346Q34592027-6FE9A1D3-E034-4D65-8C5F-0392EF63C7A6Q34598054-C939A73E-F017-4F44-B397-920B9FF7B147Q34789986-FA84E442-87EA-4D1C-9E92-F9EB1EEB8E99Q35012773-6F416E0E-E4EA-4C77-BCA4-7413B8AB978BQ35108916-C0E118BD-DDE5-4388-8B63-067BDAAB2560Q35153665-5228B7ED-0001-46B4-9D9D-2A9A166DC666Q35212329-61674D0B-1405-487C-A37D-1594A5ED1747Q35354276-588AB48B-8633-41B4-8951-81F2E392D2D4Q35816378-3C79C905-016F-4B7F-8B05-7503BA2139D6Q35990014-C55B4834-A428-4318-BE40-672A535EE45CQ36006937-443FEEE1-4A6F-461F-80AC-79D3DD47B6A0Q36088956-CC2214A7-511C-46EA-9119-1A6542514CF6Q36135264-4DC4AC47-ABD6-4F10-AAC7-C69227411817Q36185483-565AD3A8-E38C-4A91-A377-64E065EDDDDDQ36320600-764E648B-AD81-40A8-927D-26A2DE1814E8Q36321044-6A12B9A4-5DB6-4CF4-BBC7-B6E547AC300DQ36357012-D001CB8D-24CA-4D22-AB67-EB599D912E0D
P2860
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Akt activation disrupts mammar ...... n in an mTOR-dependent manner.
@ast
Akt activation disrupts mammar ...... n in an mTOR-dependent manner.
@en
type
label
Akt activation disrupts mammar ...... n in an mTOR-dependent manner.
@ast
Akt activation disrupts mammar ...... n in an mTOR-dependent manner.
@en
prefLabel
Akt activation disrupts mammar ...... n in an mTOR-dependent manner.
@ast
Akt activation disrupts mammar ...... n in an mTOR-dependent manner.
@en
P2860
P356
P1476
Akt activation disrupts mammar ...... n in an mTOR-dependent manner.
@en
P2093
Joan S Brugge
Stephanie J Walker
P2860
P304
P356
10.1083/JCB.200304159
P407
P577
2003-10-20T00:00:00Z