Regulation of rtt107 recruitment to stalled DNA replication forks by the cullin rtt101 and the rtt109 acetyltransferase.
about
RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleasesHistone H3 lysine 56 acetylation and the response to DNA replication fork damageFunctions of Ubiquitin and SUMO in DNA Replication and Replication StressRescuing stalled or damaged replication forksγH2A binds Brc1 to maintain genome integrity during S-phaseStructure of C-terminal Tandem BRCT Repeats of Rtt107 Protein Reveals Critical Role in Interaction with Phosphorylated Histone H2A during DNA Damage RepairUse of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109.DNA polymerase epsilon, acetylases and remodellers cooperate to form a specialized chromatin structure at a tRNA insulator.Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencingRole of Saw1 in Rad1/Rad10 complex assembly at recombination intermediates in budding yeastRtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNARecovery from the DNA Replication CheckpointAssembly of Slx4 signaling complexes behind DNA replication forksThe Rtt109 histone acetyltransferase facilitates error-free replication to prevent CAG/CTG repeat contractions.Smc5/6 maintains stalled replication forks in a recombination-competent conformation.Conditional genetic interactions of RTT107, SLX4, and HRQ1 reveal dynamic networks upon DNA damage in S. cerevisiae.A genetic and structural study of genome rearrangements mediated by high copy repeat Ty1 elementsRtt107 phosphorylation promotes localisation to DNA double-stranded breaks (DSBs) and recombinational repair between sister chromatids.Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast.Histone H3K56 acetylation, CAF1, and Rtt106 coordinate nucleosome assembly and stability of advancing replication forksThe role of replication bypass pathways in dicentric chromosome formation in budding yeastReplisome function during replicative stress is modulated by histone h3 lysine 56 acetylation through Ctf4.Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases.The Role of Mms22p in DNA Damage Response in Candida albicans.Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.Defective break-induced replication leads to half-crossovers in Saccharomyces cerevisiae.MTE1 Functions with MPH1 in Double-Strand Break Repair.The Rtt107 BRCT scaffold and its partner modification enzymes collaborate to promote replication.Mms1-Mms22 complex protects genome integrity in Schizosaccharomyces pombe.The S-phase checkpoint: targeting the replication fork.Nucleosome assembly and genome integrity: The fork is the link.Slx4 scaffolding in homologous recombination and checkpoint control: lessons from yeast.Multi-BRCT scaffolds use distinct strategies to support genome maintenance.Delineation of the role of chromatin assembly and the Rtt101Mms1 E3 ubiquitin ligase in DNA damage checkpoint recovery in budding yeast.Specific pathways prevent duplication-mediated genome rearrangements.Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks.Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway.Mms1 and Mms22 stabilize the replisome during replication stress.
P2860
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P2860
Regulation of rtt107 recruitment to stalled DNA replication forks by the cullin rtt101 and the rtt109 acetyltransferase.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Regulation of rtt107 recruitme ...... the rtt109 acetyltransferase.
@ast
Regulation of rtt107 recruitme ...... the rtt109 acetyltransferase.
@en
type
label
Regulation of rtt107 recruitme ...... the rtt109 acetyltransferase.
@ast
Regulation of rtt107 recruitme ...... the rtt109 acetyltransferase.
@en
prefLabel
Regulation of rtt107 recruitme ...... the rtt109 acetyltransferase.
@ast
Regulation of rtt107 recruitme ...... the rtt109 acetyltransferase.
@en
P2860
P50
P356
P1476
Regulation of rtt107 recruitme ...... the rtt109 acetyltransferase.
@en
P2093
Iram Waris Zaidi
Matthias Peter
P2860
P304
P356
10.1091/MBC.E07-09-0961
P577
2007-10-31T00:00:00Z