Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. - Wikidata - awgldk - TriplyDB

Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion.

Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion.

http://www.wikidata.org/entity/Q36326008

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Vitamins C and E: beneficial effects from a mechanistic perspective DNA Tumor Viruses and Cell Metabolism Increasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular Ascorbate HIF prolyl hydroxylase inhibitors for anemia Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response Silencing of hypoxia-inducible factor-1α gene attenuates chronic ischemic renal injury in two-kidney, one-clip rats.HIF1alpha isoforms in benign and malignant prostate tissue and their correlation to neuroendocrine differentiation.Hypoxia stimulates the expression of macrophage migration inhibitory factor in human vascular smooth muscle cells via HIF-1alpha dependent pathway Src activates HIF-1α not through direct phosphorylation of HIF-1α specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway.Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species.Hyperbaric oxygen, vasculogenic stem cells, and wound healing.Gingerol prevents prion protein-mediated neuronal toxicity by regulating HIF prolyl hydroxylase 2 and prion protein.Losartan alleviates renal fibrosis by down-regulating HIF-1α and up-regulating MMP-9/TIMP-1 in rats with 5/6 nephrectomy.Insulin regulates hypoxia-inducible factor-1α transcription by reactive oxygen species sensitive activation of Sp1 in 3T3-L1 preadipocyte.Hypoxia-inducible factor-1α contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells Mitochondrial respiratory function induces endogenous hypoxia.Enhanced hypoxia-inducible factor (HIF)-1α stability induced by 5-hydroxymethyl-2-furfural (5-HMF) contributes to protection against hypoxia.Silencing of hypoxia-inducible factor-1α gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats.Ginsenoside-Rg1 mediates a hypoxia-independent upregulation of hypoxia-inducible factor-1α to promote angiogenesis.Vitamin C deficiency activates the purine nucleotide cycle in zebrafish.Redox signalling and mitochondrial stress responses; lessons from inborn errors of metabolism.Hypoxia-inducible factor signaling in the development of kidney fibrosis Hypoxia inducible factor-1α-mediated gene activation in the regulation of renal medullary function and salt sensitivity of blood pressure.Overexpression of HIF prolyl-hydoxylase-2 transgene in the renal medulla induced a salt sensitive hypertension Myeloid cell leukemia-1 (Mc1-1) is a candidate target gene of hypoxia-inducible factor-1 (HIF-1) in the testis Reactive oxygen species in vascular formation and development.Ascorbic acid: chemistry, biology and the treatment of cancer.Angiotensin II: breathtaking in the renal medulla.Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers.Exogenous low dose hydrogen peroxide increases hypoxia-inducible factor-1alpha protein expression and induces preconditioning protection against ischemia in primary cortical neurons.Mouse models for preeclampsia: disruption of redox-regulated signaling.Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution.Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo.Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38.Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure.Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein Functional regulation of HIF-1α under normoxia--is there more than post-translational regulation?

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Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion.

http://www.wikidata.org/entity/Q36326008

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2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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Hypoxia-inducible factor-1alph ...... acellular ascorbate depletion.

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Hypoxia-inducible factor-1alph ...... acellular ascorbate depletion.

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Hypoxia-inducible factor-1alph ...... acellular ascorbate depletion.

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Hypoxia-inducible factor-1alph ...... acellular ascorbate depletion.

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Hypoxia-inducible factor-1alph ...... acellular ascorbate depletion.

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Hypoxia-inducible factor-1alph ...... acellular ascorbate depletion.

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MBC.E07-06-0612

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Molecular Biology of the Cell

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Hypoxia-inducible factor-1alph ...... acellular ascorbate depletion.

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Amato J Giaccia

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Darren E Richard

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Denise A Chan

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Elisabeth L Pagé

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Mark Levine

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P2860

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

A conserved family of prolyl-4-hydroxylases that modify HIF

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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86-94

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10.1091/MBC.E07-06-0612

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1

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17942596

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2174200

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