Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. - Wikidata - awgldk - TriplyDB

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.

http://www.wikidata.org/entity/Q36330223

about

Non-invasive metabolic imaging of brain tumours in the era of precision medicine.Simultaneous discovery of cancer subtypes and subtype features by molecular data integration.p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates.From Krebs to clinic: glutamine metabolism to cancer therapy.pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells.Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner.Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism.Tumour microenvironment factors shaping the cancer metabolism landscape.Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape.Glutamine at focus: versatile roles in cancer.Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.Mitochondria and Cancer.Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor.FREQUENT SUBGRAPH MINING OF PERSONALIZED SIGNALING PATHWAY NETWORKS GROUPS PATIENTS WITH FREQUENTLY DYSREGULATED DISEASE PATHWAYS AND PREDICTS PROGNOSIS.Brain metastasis: Unique challenges and open opportunities.Targeting amino acid metabolism for cancer therapy.Glutamine Addiction In Gliomas.Glutamine Metabolism in Cancer: Understanding the Heterogeneity.Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine.Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM).Nutrient acquisition strategies of mammalian cells.Metabolic Interactions in the Tumor Microenvironment.A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus.Profiling of the metabolic transcriptome via single molecule molecular inversion probes.Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues.Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death.The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling.Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect.Fluorination at the 4 position alters the substrate behavior of L-glutamine and L-glutamate: Implications for positron emission tomography of neoplasias.Rethinking glutamine addiction.Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease.Targeting β-catenin in hepatocellular cancers induced by coexpression of mutant β-catenin and K-Ras in mice.Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

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P2860

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.

http://www.wikidata.org/entity/Q36330223

description

2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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2015年學術文章

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2015年學術文章

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name

Glutamine synthetase activity ...... amine-restricted glioblastoma.

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Glutamine synthetase activity ...... amine-restricted glioblastoma.

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type

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Glutamine synthetase activity ...... amine-restricted glioblastoma.

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Glutamine synthetase activity ...... amine-restricted glioblastoma.

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prefLabel

Glutamine synthetase activity ...... amine-restricted glioblastoma.

@ast

Glutamine synthetase activity ...... amine-restricted glioblastoma.

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Nature Cell Biology

P1476

Glutamine synthetase activity ...... tamine-restricted glioblastoma

@en

P2093

Adam Weinstock

http://www.w3.org/2001/XMLSchema#string

Anaïs Oudin

http://www.w3.org/2001/XMLSchema#string

Andreas K Hock

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Anthony J Chalmers

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Eytan Ruppin

http://www.w3.org/2001/XMLSchema#string

Fred Fack

http://www.w3.org/2001/XMLSchema#string

Hrvoje Miletic

http://www.w3.org/2001/XMLSchema#string

Liang Zheng

http://www.w3.org/2001/XMLSchema#string

Morten Lund-Johansen

http://www.w3.org/2001/XMLSchema#string

Per Øystein Sakariassen

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Bright and stable near-infrared fluorescent protein for in vivo imaging

Global reconstruction of the human metabolic network based on genomic and bibliomic data

Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development

Flux imbalance analysis and the sensitivity of cellular growth to changes in metabolite pools

Comprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of glioblastoma

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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1556-1568

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10.1038/NCB3272

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12

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17

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Saverio Tardito

Simone P Niclou

Susan C Barnett

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2015-11-23T00:00:00Z

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284560268

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26595383

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4663685

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