PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines. - Wikidata - awgldk - TriplyDB

PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines.

PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines.

http://www.wikidata.org/entity/Q36334073

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Integrating Immune Checkpoint Blockade with Anti-Neo/Mutated Antigens Reactivity to Increase the Clinical Outcome of Immunotherapy Immune Checkpoint Blockade: A New Paradigm in Treating Advanced Cancer The anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients Control of CD8 T-Cell Infiltration into Tumors by Vasculature and Microenvironment Overcoming T cell exhaustion in infection and cancer Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy Combination Approaches with Immune-Checkpoint Blockade in Cancer Therapy PD-1 Pathway Inhibitors: Immuno-Oncology Agents for Restoring Antitumor Immune Responses Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk.Intratumoral interferon-gamma increases chemokine production but fails to increase T cell infiltration of human melanoma metastases.TLR2/6 agonists and interferon-gamma induce human melanoma cells to produce CXCL10 T cells in the human metastatic melanoma microenvironment express site-specific homing receptors and retention integrins Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity.Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells Immunotherapy in pancreatic cancer: Unleash its potential through novel combinations.Interferons and their stimulated genes in the tumor microenvironment BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease.Clinical application of genetically modified T cells in cancer therapy.Programmed death-1 blockade enhances the antitumor effects of peptide vaccine-induced peptide-specific cytotoxic T lymphocytes.Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells.Novel immune checkpoint blocker approved for the treatment of advanced melanoma Accumulation of memory precursor CD8 T cells in regressing tumors following combination therapy with vaccine and anti-PD-1 antibody.Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environment.Enhancement of T cell recruitment and infiltration into tumours.Current advances in T-cell-based cancer immunotherapy IFNγ producing CD8(+) T cells modified to resist major immune checkpoints induce regression of MHC class I-deficient melanomas STAT3 in CD8+ T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 Axis.Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology The synergistic interaction between the calcineurin B subunit and IFN-γ enhances macrophage antitumor activity.Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth.Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma.Infiltrating T cells promote renal cell carcinoma (RCC) progression via altering the estrogen receptor β-DAB2IP signals.CD8 engineered cytotoxic T cells reprogram melanoma tumor environment.Trial Watch: Adoptive cell transfer for anticancer immunotherapy.Molecular Pathways: Breaking the Epithelial Cancer Barrier for Chimeric Antigen Receptor and T-cell Receptor Gene Therapy Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies.Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.

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PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines.

http://www.wikidata.org/entity/Q36334073

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PD-1 blockade enhances T-cell ...... ng IFN-γ inducible chemokines.

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PD-1 blockade enhances T-cell ...... ng IFN-γ inducible chemokines.

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Cancer Research

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Chengwen Liu

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Chunyu Xu

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Gregory Lizée

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Hideo Yagita

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Jieqing Chen

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Laszlo Radvanyi

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Patrick Hwu

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Weiyi Peng

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Willem W Overwijk

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Yan Yang

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P2860

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target

Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

Early T cell signalling is reversibly altered in PD-1+ T lymphocytes infiltrating human tumors

Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

Restoring function in exhausted CD8 T cells during chronic viral infection

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3476734

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