mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. - Wikidata - awgldk - TriplyDB

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

http://www.wikidata.org/entity/Q36336689

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Mechanism-based management for mucositis: option for treating side effects without compromising the efficacy of cancer therapy Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond Changes in Regenerative Capacity through Lifespan Rapalogs in cancer prevention: anti-aging or anticancer?Radiation-Induced Bystander Response: Mechanism and Clinical Implications New approaches to radiation protection Human keratinocytes have two interconvertible modes of proliferation.Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death Lysosome-mediated processing of chromatin in senescence.Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer.Latest progress in tyrosine kinase inhibitors Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism From rapalogs to anti-aging formula.A Small Molecule Screen Exposes mTOR Signaling Pathway Involvement in Radiation-Induced Apoptosis mTOR Signaling from Cellular Senescence to Organismal Aging Mitochondria are required for pro-ageing features of the senescent phenotype.Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.Senescence and apoptosis: dueling or complementary cell fates?Gerosuppression in confluent cells.Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescence Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes.Novel method for proliferation of oral keratinocyte stem cells.Translational regulation of GPx-1 and GPx-4 by the mTOR pathway.The Rapalogue, CCI-779, improves salivary gland function following radiation.SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.The circadian clock in skin: implications for adult stem cells, tissue regeneration, cancer, aging, and immunity Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.The Role of Autophagy in Salivary Gland Homeostasis and Stress Responses.Cell lineage responses to photobiomodulation therapy.mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.Fasting levels of hepatic p-S6 are increased in old mice Let-7 inhibits self-renewal of hepatocellular cancer stem-like cells through regulating the epithelial-mesenchymal transition and the Wnt signaling pathway Rejuvenating immunity: "anti-aging drug today" eight years later.Koschei the immortal and anti-aging drugs Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).Inhibition of mTOR sensitizes breast cancer stem cells to radiation-induced repression of self-renewal through the regulation of MnSOD and Akt.Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition.

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mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

http://www.wikidata.org/entity/Q36336689

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

mTOR inhibition prevents epith ...... m radiation-induced mucositis.

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mTOR inhibition prevents epith ...... m radiation-induced mucositis.

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type

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mTOR inhibition prevents epith ...... m radiation-induced mucositis.

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mTOR inhibition prevents epith ...... m radiation-induced mucositis.

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mTOR inhibition prevents epith ...... m radiation-induced mucositis.

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mTOR inhibition prevents epith ...... m radiation-induced mucositis.

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J.STEM.2012.06.007

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mTOR inhibition prevents epith ...... om radiation-induced mucositis

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Alfredo A Molinolo

http://www.w3.org/2001/XMLSchema#string

Ana Cotrim

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James B Mitchell

http://www.w3.org/2001/XMLSchema#string

Kantima Leelahavanichkul

http://www.w3.org/2001/XMLSchema#string

Vyomesh Patel

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P2860

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

mTOR: from growth signal integration to cancer, diabetes and ageing

Epidermal homeostasis: a balancing act of stem cells in the skin

AKT/PKB signaling: navigating downstream

SOD2 deficiency promotes aging phenotypes in mouse skin

Global cancer statistics, 2002

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

Chemokine signaling via the CXCR2 receptor reinforces senescence

Augmented Wnt signaling in a mammalian model of accelerated aging

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401-414

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10.1016/J.STEM.2012.06.007

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3

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11

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Ramiro Iglesias-Bartolome

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2012-09-01T00:00:00Z

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230836319

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3477550

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