Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.
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Experimental models of hepatotoxicity related to acute liver failureAcetaminophen-induced Liver Injury: from Animal Models to HumansOxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potentialEvidence of reduced oral bioavailability of paracetamol in rats following multiple ingestion of grapefruit juiceNew therapeutic approach: diphenyl diselenide reduces mitochondrial dysfunction in acetaminophen-induced acute liver failurePredose and Postdose Blood Gene Expression Profiles Identify the Individuals Susceptible to Acetaminophen-Induced Liver Injury in RatsAttenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in MiceMethanol extract of Dicranopteris linearis L. leaves impedes acetaminophen-induced liver intoxication partly by enhancing the endogenous antioxidant system.Hepatoprotective Effect of Polyphenol-Enriched Fraction from Folium Microcos on Oxidative Stress and Apoptosis in Acetaminophen-Induced Liver Injury in MiceMechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology.Is nuclear factor erythroid 2-related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in mice?Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.Identification of a metabolic biomarker panel in rats for prediction of acute and idiosyncratic hepatotoxicity.Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes.Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humansPleurotus ostreatus opposes mitochondrial dysfunction and oxidative stress in acetaminophen-induced hepato-renal injury.Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo.MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury.A Cytochrome P450-Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse HepatocytesAcetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients.Amelioration of ischemia-reperfusion-induced muscle injury by the recombinant human MG53 proteinScreening and identification of hepatotoxic component in Evodia rutaecarpa based on spectrum-effect relationship and UPLC-Q-TOFMS.Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury.In vitro assessment of hepatoprotective agents against damage induced by acetaminophen and CCl4.Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytesBenzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher dosesModels of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.Hepatoprotective Activity of Herbal Composition SAL, a Standardize Blend Comprised of Schisandra chinensis, Artemisia capillaris, and Aloe barbadensis.Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.N-Acetyl cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old miceSubtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis.Quercitrin from Toona sinensis (Juss.) M.Roem. Attenuates Acetaminophen-Induced Acute Liver Toxicity in HepG2 Cells and Mice through Induction of Antioxidant Machinery and Inhibition of Inflammation.Connexin32: a mediator of acetaminophen-induced liver injury?Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver.Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanismComparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer.Effects of acetaminophen on mitochondrial complex I activity in the rat liver and kidney: a PET study with 18F-BCPP-BF.
P2860
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P2860
Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Acetaminophen-induced liver in ...... in the mechanism of toxicity.
@ast
Acetaminophen-induced liver in ...... in the mechanism of toxicity.
@en
type
label
Acetaminophen-induced liver in ...... in the mechanism of toxicity.
@ast
Acetaminophen-induced liver in ...... in the mechanism of toxicity.
@en
prefLabel
Acetaminophen-induced liver in ...... in the mechanism of toxicity.
@ast
Acetaminophen-induced liver in ...... in the mechanism of toxicity.
@en
P2093
P2860
P50
P1476
Acetaminophen-induced liver in ...... s in the mechanism of toxicity
@en
P2093
Anup Ramachandran
C David Williams
Hartmut Jaeschke
P2860
P304
P356
10.1016/J.TAAP.2012.08.015
P577
2012-08-23T00:00:00Z